Skip to main content

Table 1 Demographic, clinical and CSF characteristics by HIV status

From: Mortality in hospitalized patients with tuberculous meningitis

  Total (n = 263) HIV Positive (n = 100) HIV Negative (n = 163) p-value
Age (years)a 35 (18–84) 35 (18–74) 35 (18–84) 0.899
Male 191 (72.6%) 81 (81.0%) 110 (67.4%) 0.010
TB history 63 (24.0%) 34 (34.0%) 29 (17.8%) 0.002
MDR-TB history 6 (2.28%) 5 (5.0%) 1 (0.3%) 0.030
TB contact 70 (26.7%) 21 (21.0%) 49 (30.1%) 0.116
Alcoholism / Drug addiction 60 (22.8%) 34 (34.0%) 26 (15.9%) 0.001
Symptoms > 7 days 199 (76.1%) 82 (82.0%) 117 (71.8%) 0.075
Weight loss 129 (50.9%) 59 (59.6%) 70 (45.5%) 0.029
Headache 200 (79.1%) 81 (81.0%) 119/154 (77.3%) 0.431
Fever 182 (72.0%) 72 (72.0%) 110/154 (71.4%) 0.886
Altered level of Consciousness 173 (68.1%) 58 (58.0%) 115/155 (74.2%) 0.013
Focal neurologic deficits 91 (36.0%) 31 (31.3%) 60 (38.9%) 0.020
BMRC stage
 I 93 (35.3%) 39 (39.0%) 54 (33.1%) 0.502
 II 133 (50.6%) 46 (46.0%) 87 (53.4%)  
 III 37 (14.1%) 15 (15.0%) 22 (13.5%)  
 WBCb > 10,000 cells/uL 74/253 (29.3%) 15/99 (15.2%) 59/154 (38.3%) < 0.001
 Hyponatremia 146/219 (66.7%) 64/85 (75.3%) 82/134 (61.2%) 0.039
 CD4 counta   60 (1–874)   
 CD4 < 200   64/81 (79.0%)   
 Detectable HIV Viral load   76/77 (98.7%)   
CSF Analysis
 Proteina 213 (10–6000) 226 (12–1200) 210 (10–6000) 0.550
 Glucosea 32 (10–118) 33.2 (13.5–82) 31 (10–118) 0.595
 Leucocytesa 80 (1–3808) 56 (1–1550) 90 (1–3808) 0.040
 Mononuclear cells (%)a 98 (5–100) 100 (15–100) 95 (5–100) 0.010
 ADAa 10 (0.8–76.1) 9.8 (0.9–53.3) 10 (0.9–76.1) 0.974
  1. a Median (range), b White blood cell count