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Table 8 Sub-distribution hazard ratio’s for fluoroquinolones during admission

From: Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

 

Working diagnosis of CAP

N = 2107; 146 n/w cardiac events

Radiologically proven CAP

N = 1604; 115 n/w cardiac events

Outcome

antibiotic

Crude HR (CI)

Adjusted HR (CI)

Crude HR (CI)

Adjusted HR (CI)

n/w cardiac event

ciprofloxacin

1.09 (0.61;1.94)

0.95 (0.53;1.70)

1.18 (0.64;2.17)

1.00 (0.54;1.85)

levofloxacin

0.49 (0.23;1.07)

0.52 (0.24;1.13)

0.40 (0.15;1.11)

0.43 (0.15;1.18)

moxifloxacin

0.68 (0.44;1.06)

0.68 (0.43;1.06)

0.65 (0.40;1.07)

0.66 (0.40;1.10)

n/w Heart failure

ciprofloxacin

1.05 (0.52;2.10)

0.91 (0.46;1.84)

1.06 (0.51;2.24)

0.89 (0.42;1.87)

levofloxacin

0.31 (0.10;0.98)

0.33 (0.10;1.05)

0.14 (0.02;1.02)

0.15 (0.02;1.08)

moxifloxacin

0.58 (0.33;1.01)

0.60 (0.35;1.06)

0.53 (0.29;1.00)

0.57 (0.30;1.06)

n/w Arrhythmia

ciprofloxacin

1.19 (0.46;3.04)

1.04 (0.40;2.66)

1.08 (0.38;3.10)

0.93 (0.32;2.66)

levofloxacin

0.62 (0.19;2.05)

0.61 (0.19;2.02)

0.88 (0.26;2.95)

0.87 (0.26;2.91)

moxifloxacin

0.81 (0.40;1.65)

0.82 (0.40;1.65)

0.86 (0.40;1.83)

0.89 (0.42;1.89)

  1. n/w = new or worsening
  2. Sub-distribution hazard ratio’s (SDHR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different fluoroquinolones during admission on cardiac events. Adjusted SDHR’s are adjusted for confounders mentioned in Methods