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Table 8 Sub-distribution hazard ratio’s for fluoroquinolones during admission

From: Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

  Working diagnosis of CAP
N = 2107; 146 n/w cardiac events
Radiologically proven CAP
N = 1604; 115 n/w cardiac events
Outcome
antibiotic
Crude HR (CI) Adjusted HR (CI) Crude HR (CI) Adjusted HR (CI)
n/w cardiac event
ciprofloxacin 1.09 (0.61;1.94) 0.95 (0.53;1.70) 1.18 (0.64;2.17) 1.00 (0.54;1.85)
levofloxacin 0.49 (0.23;1.07) 0.52 (0.24;1.13) 0.40 (0.15;1.11) 0.43 (0.15;1.18)
moxifloxacin 0.68 (0.44;1.06) 0.68 (0.43;1.06) 0.65 (0.40;1.07) 0.66 (0.40;1.10)
n/w Heart failure
ciprofloxacin 1.05 (0.52;2.10) 0.91 (0.46;1.84) 1.06 (0.51;2.24) 0.89 (0.42;1.87)
levofloxacin 0.31 (0.10;0.98) 0.33 (0.10;1.05) 0.14 (0.02;1.02) 0.15 (0.02;1.08)
moxifloxacin 0.58 (0.33;1.01) 0.60 (0.35;1.06) 0.53 (0.29;1.00) 0.57 (0.30;1.06)
n/w Arrhythmia
ciprofloxacin 1.19 (0.46;3.04) 1.04 (0.40;2.66) 1.08 (0.38;3.10) 0.93 (0.32;2.66)
levofloxacin 0.62 (0.19;2.05) 0.61 (0.19;2.02) 0.88 (0.26;2.95) 0.87 (0.26;2.91)
moxifloxacin 0.81 (0.40;1.65) 0.82 (0.40;1.65) 0.86 (0.40;1.83) 0.89 (0.42;1.89)
  1. n/w = new or worsening
  2. Sub-distribution hazard ratio’s (SDHR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different fluoroquinolones during admission on cardiac events. Adjusted SDHR’s are adjusted for confounders mentioned in Methods