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Table 7 Sub-distribution hazard ratio’s for macrolides during admission

From: Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

  Working diagnosis of CAP
N = 2107; 146 n/w cardiac events
Radiologically proven CAP
N = 1604; 115 n/w cardiac events
Outcome
antibiotic
Crude HR (CI) Adjusted HR (CI) Crude HR (CI) Adjusted HR (CI)
n/w Cardiac event
azithromycin 0.86 (0.48;1.53) 0.93 (0.52;1.67) 0.73 (0.37;1.46) 0.84 (0.42;1.68)
clarithromycin 1.11 (0.68;1.83) 1.34 (0.81;2.22) 1.19 (0.70;2.04) 1.47 (0.85;2.52)
erythromycin 1.73 (1.17;2.55) 1.99 (1.35;2.94) 1.66 (1.08;2.56) 1.87 (1.21;2.88)
n/w Heart failure
azithromycin 0.90 (0.46;1.74) 1.00 (0.51;1.94) 0.76 (0.35;1.67) 0.91 (0.41;2.00)
clarithromycin 1.25 (0.71;2.20) 1.57 (0.89;2.79) 1.26 (0.68;2.33) 1.67 (0.89;3.12)
erythromycin 2.06 (1.33;3.18) 2.35 (1.52;3.65) 1.84 (1.13;3.00) 2.01 (1.23;3.28)
n/w Arrhythmia
azithromycin 1.22 (0.51;2.91) 1.28 (0.54;3.07) 0.96 (0.33;2.73) 1.09 (0.38;3.14)
clarithromycin 1.02 (0.42;2.47) 1.18 (0.48;2.85) 1.21 (0.49;2.98) 1.43 (0.57;3.55)
erythromycin 1.37 (0.69;2.74) 1.44 (0.72;2.88) 1.44 (0.68;3.02) 1.49 (0.71;3.15)
  1. n/w = new or worsening
  2. Sub-distribution hazard ratio’s (SDHR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different macrolides during admission on cardiac events. Adjusted SDHR’s are adjusted for confounders mentioned in Methods