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Table 6 Hazard ratio’s for fluoroquinolones during admission

From: Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

  Working diagnosis of CAP
N = 2107; 146 n/w cardiac events
Radiologically proven CAP
N = 1604; 115 n/w cardiac events
Outcome
antibiotic
Crude HR (CI) Adjusted HR (CI) Crude HR (CI) Adjusted HR (CI)
n/w cardiac event
ciprofloxacin 0.77 (0.43;1.37) 0.70 (0.39;1.26) 0.81 (0.44;1.50) 0.72 (0.39;1.33)
levofloxacin 0.40 (0.18;0.87) 0.43 (0.20;0.93) 0.33 (0.12;0.91) 0.36 (0.13;0.98)
moxifloxacin 0.56 (0.36;0.87) 0.56 (0.36;0.88) 0.53 (0.32;0.86) 0.54 (0.33;0.89)
n/w Heart failure
ciprofloxacin 0.71 (0.36;1.44) 0.65 (0.32;1.31) 0.71 (0.34;1.50) 0.62 (0.29;1.31)
levofloxacin 0.25 (0.08;0.80) 0.27 (0.08;0.86) 0.12 (0.02;0.85) 0.12 (0.02;0.88)
moxifloxacin 0.48 (0.27;0.84) 0.50 (0.28;0.87) 0.43 (0.23;0.81) 0.46 (0.24;0.85)
n/w Arrhythmia
ciprofloxacin 0.83 (0.32;2.12) 0.75 (0.29;1.93) 0.73 (0.25;2.09) 0.64 (0.22;1.86)
levofloxacin 0.50 (0.15;1.64) 0.49 (0.15;1.62) 0.71 (0.21;2.39) 0.70 (0.21;2.35)
moxifloxacin 0.66 (0.33;1.34) 0.66 (0.33;1.34) 0.69 (0.32;1.46) 0.71 (0.33;1.51)
  1. n/w = new or worsening
  2. Hazard ratio’s (HR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different fluoroquinolones during admission on cardiac events. Adjusted HR’s are adjusted for confounders mentioned in Methods