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Table 5 Hazard ratio’s for macrolides during admission

From: Cardiac events after macrolides or fluoroquinolones in patients hospitalized for community-acquired pneumonia: post-hoc analysis of a cluster-randomized trial

  Working diagnosis of CAP
N = 2107; 146 n/w cardiac events
Radiologically proven CAP
N = 1604; 115 n/w cardiac events
Outcome
antibiotic
Crude HR (CI) Adjusted HR (CI) Crude HR (CI) Adjusted HR (CI)
n/w Cardiac event
azithromycin 0.70 (0.39;1.26) 0.76 (0.42;1.35) 0.59 (0.29;1.18) 0.66 (0.33;1.32)
clarithromycin 0.84 (0.51;1.38) 1.03 (0.62;1.70) 0.88 (0.52;1.51) 1.09 (0.63;1.88)
erythromycin 1.60 (1.09;2.36) 1.82 (1.23;2.68) 1.53 (1.00;2.35) 1.67 (1.09;2.57)
n/w Heart failure
azithromycin 0.73 (0.38;1.41) 0.78 (0.40;1.52) 0.61 (0.28;1.35) 0.69 (0.32;1.53)
clarithromycin 0.93 (0.53;1.64) 1.17 (0.66;2.08) 0.92 (0.49;1.70) 1.20 (0.64;2.24)
erythromycin 1.89 (1.22;2.91) 2.11 (1.36;3.26) 1.67 (1.03;2.71) 1.77 (1.09;2.87)
n/w Arrhythmia
azithromycin 1.00 (0.42;2.39) 1.03 (0.43;2.47) 0.77 (0.27;2.21) 0.85 (0.30;2.45)
clarithromycin 0.76 (0.31;1.84) 0.87 (0.36;2.12) 0.88 (0.36;2.17) 1.02 (0.41;2.53)
erythromycin 1.25 (0.62;2.49) 1.28 (0.64;2.57) 1.30 (0.62;2.72) 1.32 (0.63;2.78)
  1. n/w = new or worsening
  2. Hazard ratio’s (HR’s) with 95% confidence intervals (CIs) from Cox PH models for time-dependent exposure to different macrolides during admission on cardiac events. Adjusted HR’s are adjusted for confounders mentioned in Methods