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Table 1 The comparative histopathological lesions of intestines between Crohn’s and Johne’s diseases

From: Prevalence of Mycobacterium avium subspecies paratuberculosis IS 900 DNA in biopsy tissues from patients with Crohn’s disease: histopathological and molecular comparison with Johne’s disease in Fars province of Iran

Lesions/diseases CD JD
N/30(%) S N/30(%) S
Diffuse multibacillary granulomatous enteritis 0 (0%) 13 (43%) +++
Diffuse granulomatous enteritis 6 (20%) + 10 (33%) ++
Focal- multifocal granulomatous enteritis 19 (63%) ++ 4 (14%) +
lymphoplasmacytic enteritis 5 (17%) + + 3 (10%) ++
Lymphangiectasia/edema 20 (67%) +++ 29 (96%) +++
Vasculitis/lymphangitis 6 (20%) + 22 (73%) +++
Lymphoid hyperplasia 10 (33%) ++ 13 (43%) ++
Neuritis/neuronal hyperplasia 11 (36%) ++ 13 (43%) ++
Cryptitis 12 (40%) ++ 4 (14%) +
Crypt abscesses 10 (33%) ++ 3 (10%) +
Ulceration 22 (73%) +++ 0
Fibrosis 16 (53%) ++ 0
Pyloric gland metaplasia 12 (40%) ++ 0
Thrombosis 9 (30%) ++ 0
Paneth cell metaplasia/hyperplasia 5 (17%) + 0 -
Goblet cell hyperplasia 4 (14%) + 0 -
  1. JD Johne’s disease, CD Crohn’s disease, N Number, S Severity, +, mild, ++, moderate, +++, severe