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Table 2 Age, sex, CSF analyses and outcome of patients with microorganism detected in CSF sample

From: New molecular tools for meningitis diagnostics in Ethiopia – a necessary step towards improving antimicrobial prescription

   

CSF analyses

Sex

Age range

Antibiotics prior to sampling

PCRa

Appearance

Cell count

% Neutrophils

% Lymphocytes

Gram-stain and microscopy

Culture

Outcome

M

< 1 month

Unknown

Enterovirus

Bloody

No cells

  

No organism seen

Negative

Improved

F

< 1 month

No

Enterovirus

Clear

25

0

100

No organism seen

Negative

Unknown

M

1–12 months

No

Herpes simplex virus 1

Bloody

N.Db

  

No organism seen

Negative

Improved

M

> 20 years

Yes

Herpes simplex virus 1

Xanthochromic

152

0

100

No organism seen

Negative

Died

F

> 20 years

Yes

Herpes simplex virus 1

Clear

No cells

  

No organism seen

Negative

Unknown

F

> 20 years

No

Herpes simplex virus 2

Clear

250

0

100

No organism seen

Negative

Unknown

M

< 1 month

Yes

Human herpes virus 6

Clear

5

0

100

No organism seen

Negative

Improved

M

< 1 month

No

Human herpes virus 6

Clear

8

0

100

No organism seen

Negative

Improved

F

1–12 months

No

Human herpes virus 6

Clear

No cells

  

No organism seen

Negative

Improved

M

1–5 years

No

Human herpes virus 6

Clear

No cells

  

No organism seen

Negative

Improved

F

6–10 years

Yes

Human herpes virus 6

Clear

332

1

99

No organism seen

Negative

Improved

M

> 20 years

No

Varicella zoster virus

Clear

No cells

  

No organism seen

Negative

Same condition

F

> 20 years

No

Escherichia coli

Clear

75

60

40

No organism seen

Negative

Same condition

M

1–5 years

No

Haemophilus influenzae

Turbid

40,000

95

5

Gram negative rods

Negative

Improved

M

10–20 years

No

Haemophilus influenzae

Turbid

5200

90

10

No organism seen

Negative

Left hospital against medical advice

M

4 years

Yes

Neisseria meningitidis

Turbid

4200

80

20

No organism seen

Negative

Improved

M

1–12 months

No

Streptococcus pneumoniae

Turbid

2500

10

90

Gram positive cocci

Negative

Improved

M

10–20 years

No

Streptococcus pneumoniae

Turbid

1040

70

30

No organism seen

Negative

Unknown

M

< 1 month

No

Negative

Turbid

1000

10

90

No organism seen

Klebsiella pneumoniae

Died

F

> 20 years

No

Cryptococcusc

Turbid

13

0

100

Fungal elements

Negative

Died

M

> 20 years

No

Cryptococcusc

Clear

5

0

100

No organism seen

Negative

Unknown

  1. N.D. not done
  2. a FilmArray system, meningitis-encephalitis panel, from BioMerieux
  3. b Cell count not done/not possible due to bloody samples
  4. c Sample positive on cryptococcal antigen testing