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Table 2 A summary of hmAb experiments investigating neutralisation of heterologous flavivirus infection

From: Cross-reactive dengue virus-derived monoclonal antibodies to Zika virus envelope protein: Panacea or Pandora’s box?

Antibody Name Target Epitope Cell line Neutralisation Measurement EC50/PRNT50 Concentration (μg/ml)
1.6D [13] FLE LLC-MK2 Focus forming assay Up to 40
D11C [13] FLE LLC-MK2 Focus forming assay Up to 40
ZKA3 [14]* EDI/II Vero Flow cytometry 0.35
ZKA78 [14]* EDI/II Vero Flow cytometry 0.27
2A10G6 [19] FLE BHK-21 PRNT 250
752-2C8 [18] EDE1 Vero Focus forming assay 8.9 × 10− 4
753 (3) C10 [18] EDE1 Vero Focus forming assay 3.4 × 10− 4
B7 [18] EDE2 Vero Focus forming assay Unknown
  1. PRNT Plaque Reduction Neutralisation Test
  2. * = hmAbs taken from ZIKV-infected donors and tested for neutralisation of DENV infection
  3. EC50/PRNT50 concentrations quoted to 2 significant figures