Cross-reactive dengue virus-derived monoclonal antibodies to Zika virus envelope protein: Panacea or Pandora’s box?

Table 1 A summary of hmAb experiments investigating ADE of heterologous flavivirus infection

Antibody Name	Concentration (μg/ml)	Target Epitope	Cell line	ADE Measurement	Enhancement Strength
31.3F01 [11]	0.4	Unknown	U937	Flow cytometry	48x
1.6D [13]	20	FLE	K562	qRT-PCR	140x
D11C [13]	20	FLE	K562	qRT-PCR	275x
ZKA3 [14]*	1	EDI/II	K562	Flow cytometry	~75x
ZKA78 [14]*	1	EDI/II	K562	Flow cytometry	~60x
DV82 [14]	1	EDI/II	K562	Flow cytometry	~16x
753(3) C10 [15]	0.1nM**	EDE1	U937	Focus forming assay	~80x
747(4) A11 [15]	1nM**	EDE2	U937	Focus forming assay	~90x
750-2C5 [15]	1nM**	FLE	U937	Focus forming assay	~60x

qRT-PCR quantitative reverse transcription polymerase chain reaction
* = hmAbs taken from ZIKV-infected donors and tested for enhancement of DENV infection
** = Molar mass not quoted in paper so unable to convert to μg/ml
~ = Approximation as values read from graph

ISSN: 1471-2334