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Table 6 Test performance characteristics; comparison with earlier studies performed by other groups

From: Laboratory evaluation of four HIV/syphilis rapid diagnostic tests

  SD Bioline HIV/Syphilis Duo DPP HIV-Syphilis Assay Multiplo Rapid TP/HIV Antibody Test Insti Multiplex HIV-1/HIV-2/Syphilis Antibody Test
Antibodies to HIV
Sensitivity (%)
  This evaluation (95% CI) 100 (98.2–100) 100 (98.2–100) 99.5 (97.2–100) 99.5 (97.2–100)
  Previous laboratory evaluationsa 97.1–100 98.8–100 97.9–100 100
  Previous field evaluationsa 98.8–99.2 NA 93.8 93.8
Specificity (%)
  This evaluation 99.5 (97.2–100) 97.5 (94.3–99.2) 99.5 (97.2–100) 93.5 (89.1–96.5)
  Previous laboratory evaluationsa 99.5–100 97.9–98.7 91.9–98.3 95.5
  Previous field evaluationsa 97.0–100 NA 100 100
Antibodies to Treponema pallidum
Sensitivity (%)
  This evaluation (95% CI) 87.0 (81.5–91.3) 86.5 (81.0–90.9) 73.5 (66.8–79.5) 81.0 (74.9–86.2)
  Previous laboratory evaluationsa 72.2–100 82.5–98.8 80.7–94.6 87.4
  Previous field evaluationsa 66.7–96.5 NA 81 81.0
Specificity (%)
  This evaluation 99.5 (97.2–100) 100 (98.2–100) 99.5 (97.2–100) 99.0 (96.4–99.9)
  Previous laboratory evaluationsa 96.0–100 96.4–100 88.7–97.2 97.0
 Previous field evaluationsa 90.8–98.8 NA 100 100
  1. SD Bioline previous laboratory evaluations: references [5, 7, 12,13,14, 16, 17, 20, 21, 23, 24]; SD Bioline previous field evaluations: references [8, 11, 15]; DPP previous laboratory evaluations: references [5, 17,18,19, 23]; Multiplo previous laboratory evaluations: references [5, 6, 17, 23]; Multiplo previous field evaluations: reference [10]; Insti previous laboratory evaluation: reference [9]
  2. NA Not available
  3. arange from lowest obtained sensitivity or specificity to highest