Comments | |
---|---|
Exhaustive history record | |
infant respiratory diseases | croup, Influenza, measle |
gastro-oesophageal reflux disease | |
atopic dermatitis | |
eating disorders | anorexia, bulimia |
family history of respiratory disease | |
prior tuberculosis | |
prior anti-NTM treatment | |
Environmental exposure | |
passive tobacco exposure | |
active tobacco smocking | Packs-per-year |
other toxic/drug exposure | |
chronic alcoholism | micro-inhalations |
habitat characteristics | domestic water system, allergens |
Blood tests | |
serum albumin | nutritional status |
serum pre-albumin | |
vitamin D (25-OH D3) | |
HIV serology | cellular immune defect |
T CD4+ and CD8+ lymphocyte counts | |
total IgG serum level | hypogammaglobulinemia |
total eosinophil count | Aspergillus-related allergic lung diseases |
total IgE serum level | |
Aspergillus-specific IgE | |
Aspergillus serology | |
galactomannan antigenemia | invasive aspergillosis |
Interferon-γ reactive assay | latent tuberculosis infection |
Lung function testing | |
spirometry including FEV1 | lung volumes |
plethysmography | |
pulse oxymetry | oxygen level |
arterial blood gas tests | |
6-minutes walk test | stress test |
Imagery | |
chest X-ray | |
lung HRCT scan | Micronodules (≤ 5mm), nodules (≥ 10 mm), pulmonary consolidations, bronchiectasis, tree-in-bud images, cavity(ies) |
Cytology and microbiologic tests on respiratory samples | |
BALF cytological composition | |
sputum/BALF direct examination | |
sputum/BALF collection for bacterial culture | Non-fermenting gram-negative bacilli (Pseudomonas aeruginosa) |
sputum/BALF collection for mycological culture | filamentous fungi |
nasal swab/BALF collection for respiratory virus PCR screening | human Respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus |
Specific tests depending on the setting | |
α-1 antitrypsin level | lung emphysema |
sweat test | cystic fibrosis |
CFTR gene screening | |
airway cilia sample | primary ciliary dyskinesia |
IFN-γ and IL-12 plasma levels | host predisposition to NTM diseases |
blood anti-IFN-γ autoantibodies | |
IFN-γ or IL-12 gene screening |