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Table 4 Standardized appraisal for patients with nontuberculous mycobacterial lung diseases without systemic immunodeficiency referred at our institution

From: A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity

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Exhaustive history record
 infant respiratory diseases croup, Influenza, measle
 gastro-oesophageal reflux disease  
 atopic dermatitis  
 eating disorders anorexia, bulimia
 family history of respiratory disease  
 prior tuberculosis  
 prior anti-NTM treatment  
Environmental exposure
 passive tobacco exposure  
 active tobacco smocking Packs-per-year
 other toxic/drug exposure  
 chronic alcoholism micro-inhalations
 habitat characteristics domestic water system, allergens
Blood tests
 serum albumin nutritional status
 serum pre-albumin
 vitamin D (25-OH D3)
 HIV serology cellular immune defect
 T CD4+ and CD8+ lymphocyte counts
 total IgG serum level hypogammaglobulinemia
 total eosinophil count Aspergillus-related allergic lung diseases
 total IgE serum level
Aspergillus-specific IgE
Aspergillus serology
 galactomannan antigenemia invasive aspergillosis
 Interferon-γ reactive assay latent tuberculosis infection
Lung function testing
 spirometry including FEV1 lung volumes
 plethysmography
 pulse oxymetry oxygen level
 arterial blood gas tests
 6-minutes walk test stress test
Imagery
chest X-ray
 lung HRCT scan Micronodules (≤ 5mm), nodules (≥ 10 mm), pulmonary consolidations, bronchiectasis, tree-in-bud images, cavity(ies)
Cytology and microbiologic tests on respiratory samples
BALF cytological composition
sputum/BALF direct examination
 sputum/BALF collection for bacterial culture Non-fermenting gram-negative bacilli (Pseudomonas aeruginosa)
 sputum/BALF collection for mycological culture filamentous fungi
 nasal swab/BALF collection for respiratory virus PCR screening human Respiratory syncytial virus, parainfluenza virus, metapneumovirus, rhinovirus, and coronavirus
Specific tests depending on the setting
 α-1 antitrypsin level lung emphysema
 sweat test cystic fibrosis
 CFTR gene screening
 airway cilia sample primary ciliary dyskinesia
 IFN-γ and IL-12 plasma levels host predisposition to NTM diseases
 blood anti-IFN-γ autoantibodies
 IFN-γ or IL-12 gene screening
  1. Abbreviations: BALF, bronchoalveolar lavage fluid; CFTR, cystic fibrosis transmembrane conductance regulator, FEV1, forced expiratory volume in 1 second; HRCT, high-resolution computed tomography; IFN-γ, interferon gamma; Ig, immunoglobulins; IL, interleukin