Table 2 Assessment of risk of bias of studies included in the meta-analysis
| Author details | Study site | Drug regimen | Allocation sequence | Allocation concealment | Blinding | No evidence of incomplete outcome data recording | No evidence of selective outcome recording |
|---|---|---|---|---|---|---|---|
| Olaosebikan et al., 2015 | Kwara state, Nigeria |
MQAS SPAQ PG | Yes | Yes |
(Open-label) Laboratory staff were unaware of treatment allocation |
MQAS (2 withdrew consent, 3 moved away, 12 lost and 4 deaths) SPAQ (1 withdrew consent, 2 moved away and 12 lost) PG (1 moved away, 26 lost and 3 deaths) | Yes b |
| Diop et al., 2010 | Dakar, Senegal |
PL SP | Yes | Yes | Open-label | Yesa | Yes b |
| Nakibuuka et al., 2009 | Kampala, Uganda |
SP CQ | Yes | Yes | Double-blind |
SP (7 lost to follow up) CQ (8 lost to follow up) | Yes b |
| Eke et al., 2003 | Port Harcourt, Nigeria |
PL PM PG | Yes | Yes | Open-label | Yesa | Yes b |
| Nwokolo et al., 2001 | Multicenter, Nigeria |
PG MQ | Yes | Yes | Open-label | Yesa | Yes b |
| Warley et al., 1965 | Kampala, Uganda |
PL CQ + benzathine penicillin | Yes | Yes | Not provided | Yesa | No (dactylitis and Haemoglobin) |