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Table 3 Comparison of the demographic and clinical characteristics and recurrence factors in clinical studies of osteomyelitis

From: Factors predictive of relapse in adult bacterial osteomyelitis of long bones.

   Roine [13]
1996
Tice [8, 9]
2003
Arias [11]
2015
Lin [14]
2016
Present series
2017
No. patients (% males)   83 (NS) 454 (65%) 129 (80.6%) 108 (75%) 116 (74.1%)
Age group   Children (mean 6.7 y) Mostly adults (mean 51 y) Adults (range 18–91 y) Mostly adults (median 54 y) Adults (mean 53 y)
Country   Costa Rica USA Colombia Singapore Spain
Origin   Hematogenous Multiple Multiple Multiple Multiple
Post-traumatic (n, %)   0 (0%) 409 (90.1%) a 115 (89.2%) 42 (38.9%) 62 (53.4%)
Bones involved   Mostly long bones Mostly non-long bones Mostly long bones Mostly long bones Only long bones
S. aureus (n, %) b   41 (49.4%) 246 (54.2%) 49 (38.0%) 42 (38.9%) 48 (38.1%)
Diabetes   NS 173 (38.1%) 7 (5.4%) 58 (53.7%) 10 (8.6%)
Recurrence (n, %)   5 (6.0%) 139 (30.6%) 30 (23.3%) 40 (37.0%) 26 (20.6%)
Mean follow-up (months)   1.5 or 14 c 28.3 12 23,4 67.1
Factors associated with recurrence Microorganisms involved S aureus d P aeruginosa No MRSA No
Antibiotic type No d Yes (vancomycin) e No NS No
Antibiotic duration No d NS No No No
Age No d No (> 70 y) No No No
Diabetes NS d Yes No No No
Peripheral vascular disease NA d Yes No No No
Long bones NS d NS No Yes (lower limbs) No
Fracture NA d NS No No No
Symptoms duration No d NS NS NS Yes (> 3 months)
Bone exposure NA d NS No No Yes
Type of surgery No d NS NS No Yes
C-RP Yes d NS NS No No
ESR No d NS NS Yes (≥ 20 mm/h) No
  1. NA denotes not applicable, NS not studied, MSSA methicillin-susceptible Staphylococcus aureus, MRSA methicillin-resistant Staphylococcus aureus, C-RP C-reactive protein, ESR erythrocyte sedimentation rate
  2. aDescribed as associated with wounds
  3. bRespect to the total number of patients
  4. cAll patients were followed-up for a mean of at least 1,5 months, and 78% of them for a mean of 14 months
  5. dFactors associated with sequelae (28 patients, 33.7%); data for recurrence are not provided
  6. eOnly in staphylococcal infections