Table 3 Comparison of the demographic and clinical characteristics and recurrence factors in clinical studies of osteomyelitis
From: Factors predictive of relapse in adult bacterial osteomyelitis of long bones.
Roine [13] 1996 | 2003 | Arias [11] 2015 | Lin [14] 2016 | Present series 2017 | ||
|---|---|---|---|---|---|---|
No. patients (% males) | 83 (NS) | 454 (65%) | 129 (80.6%) | 108 (75%) | 116 (74.1%) | |
Age group | Children (mean 6.7 y) | Mostly adults (mean 51 y) | Adults (range 18–91 y) | Mostly adults (median 54 y) | Adults (mean 53 y) | |
Country | Costa Rica | USA | Colombia | Singapore | Spain | |
Origin | Hematogenous | Multiple | Multiple | Multiple | Multiple | |
Post-traumatic (n, %) | 0 (0%) | 409 (90.1%) a | 115 (89.2%) | 42 (38.9%) | 62 (53.4%) | |
Bones involved | Mostly long bones | Mostly non-long bones | Mostly long bones | Mostly long bones | Only long bones | |
S. aureus (n, %) b | 41 (49.4%) | 246 (54.2%) | 49 (38.0%) | 42 (38.9%) | 48 (38.1%) | |
Diabetes | NS | 173 (38.1%) | 7 (5.4%) | 58 (53.7%) | 10 (8.6%) | |
Recurrence (n, %) | 5 (6.0%) | 139 (30.6%) | 30 (23.3%) | 40 (37.0%) | 26 (20.6%) | |
Mean follow-up (months) | 1.5 or 14 c | 28.3 | 12 | 23,4 | 67.1 | |
Factors associated with recurrence | Microorganisms involved | S aureus d | P aeruginosa | No | MRSA | No |
Antibiotic type | No d | Yes (vancomycin) e | No | NS | No | |
Antibiotic duration | No d | NS | No | No | No | |
Age | No d | No (> 70 y) | No | No | No | |
Diabetes | NS d | Yes | No | No | No | |
Peripheral vascular disease | NA d | Yes | No | No | No | |
Long bones | NS d | NS | No | Yes (lower limbs) | No | |
Fracture | NA d | NS | No | No | No | |
Symptoms duration | No d | NS | NS | NS | Yes (> 3 months) | |
Bone exposure | NA d | NS | No | No | Yes | |
Type of surgery | No d | NS | NS | No | Yes | |
C-RP | Yes d | NS | NS | No | No | |
ESR | No d | NS | NS | Yes (≥ 20 mm/h) | No |