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Table 2 Treatment of cutaneous leishmaniasis. Leishmania species in cutaneous leishmaniasis cases, with first-line and second-line treatments and outcomes; data from Sweden, 1996–2016. Sodium stibogluconate (SS), liposomal amphotericin (LA), intralesional (il), intravenous (iv)

From: Cutaneous, mucocutaneous and visceral leishmaniasis in Sweden from 1996–2016: a retrospective study of clinical characteristics, treatments and outcomes

Leishmania species

Treatment

No of cases

Cured

Treatment failure

Relapse

Allergic reaction

Lost to follow-up after treatment

First-line

Second-line

L.tropica

SS (il)

3

2

0

1

0

0

 

SS + paromomycin ointment

1

1

SS (iv)

13

9

1

3

0

0

 

LA

3

1

2a

1

Paromomycin ointment

1

1

SS (iv) + Cryotherapy

2

2

0

0

0

0

LA

15

6

5

2

1 b

1c

 

SS

4

3

1

LA

1

1

Cryotherapy

1

1

Paromomycin ointment

1

1

LA + Cryotherapy

4

2

1

0

1

0

 

SS

1

1

Cryotherapy

1

1

Cryotherapy

17

16

0

1

0

0

 

SS

1

1

Fluconazole

4

0

4

0

0

0

 

SS

2

2

LA

1

1

Cryotherapy

1

1

Paromomycin ointment

1

0

1

0

0

0

 

SS (iv)

1

1

L.major

SS (il)

7

7

0

0

0

0

SS (iv)

4

4

0

0

0

0

SS + Cryotherapy

1

1

0

0

0

0

LA

1

1

0

0

0

0

Fluconazole

8

5

3

0

0

0

 

SS (iv)

1

1

Cryotherapy

1

1

Miltefosine

1

1

Cryotherapy

3

3

0

0

0

0

L. braziliensis/braziliensis complex

SS (il)

2

0

2

0

0

0

 

LA

1

1

Ketaconazole

1

1

SS (iv)

10

7

2

0

1

0

 

LA

2

1

1

Meglumine antimoniate

1

1

LA

4

2

2

0

0

0

 

SS (iv)

2

2

L. panamensis

SS (iv)

7

7

0

0

0

0

Ketoconazole

1

1

0

0

0

0

Miltefosine

1

1

0

0

0

0

Paromomycin ointment

1

1

0

0

0

0

Unspecified Leishmania species

SS (il)

2

2

0

0

0

0

SS (iv)

1

0

1

0

0

0

 

LA

1

1

Fluconazole

1

1

0

0

0

0

L. infantum

LA

4

3

1

0

0

0

 

LA

1

1

Photodynamic therapy

1

1

0

0

0

0

L. donovani

Fluconazole

2

1

1

0

0

0

 

LA

1

1

Cryotherapy

1

1

0

0

0

0

L. aethiopica

SS (iv)

1

0

1

0

0

0

 

Cryotherapy

1

1

L. braziliensis/gyanensis

LA

1

1

0

0

0

0

L. mexicana

SS (iv)

1

0

0

0

1

0

 

Ketoconazole

1

1

L. peruviana

SS (iv)

1

1

0

0

0

0

  1. a continued to relapse, both after LA as a single treatment and after LA in combination with cryotherapy; after five years, the lesions are still not cured
  2. b was lost to follow-up after a reaction during the first infusion with LA
  3. c died during follow-up, of medical reasons unrelated to Leishmania infection or anti-Leishmania treatment