A systematic review of the association between delayed appropriate therapy and mortality among patients hospitalized with infections due to Klebsiella pneumoniae or Escherichia coli: how long is too long?

Table 2 Overall Mortality by DAT Definition for Infections Due to Klebsiella pneumoniae or Escherichia coli

Definition	K. pneumoniae or E. coli Infections		K. pneumoniae Infections Alone		E. coli Infections Alone
Definition	Studies, n [Ref]	OR (95% CI)	Studies, n [Ref]	OR (95% CI)	Studies, n [Ref]	OR (95% CI)
DAT > 24 h	5 [17, 21, 23, 24, 29]	1.24 (0.85–1.80)	3 [17, 21, 29]	1.37 (0.73–2.54)	4 [17, 21, 23, 24]	1.19 (0.73–1.93)
DAT > 48 h	4 [12, 15, 26, 28]	1.33 (0.84–2.12)	1 [26]	a	2 [15, 28]	1.86 (1.23–2.80)
DAT > 72 h	4 [13, 18, 19, 25]	2.12 (0.66–6.79)	2 [13, 19]	1.93 (0.25–12.48)	1 [25]	a
DAT > C& SR	7 [11, 14, 16, 20, 22, 27, 30]	2.06 (1.36–3.12)	3 [11, 16, 22]	1.93 (1.29–2.89)	1 [20]	a
All (Any DAT > 24 or DAT > C& SR)	20 [11–30]	1.60 (1.25–2.05)	9 [11, 13, 16, 17, 19, 21, 22, 26, 29]	1.53 (1.07–2.17)	8 [15, 17, 18, 20, 21, 23, 24, 28]	1.49 (1.10–2.01)

C& SR culture and susceptibility reporting, DAT delayed appropriate therapy, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, OR odds ratio
^aAnalysis not possible owing to the identification of only 1 study with outcomes reported at the indicated time point for delay

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