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Table 2 Overall Mortality by DAT Definition for Infections Due to Klebsiella pneumoniae or Escherichia coli

From: A systematic review of the association between delayed appropriate therapy and mortality among patients hospitalized with infections due to Klebsiella pneumoniae or Escherichia coli: how long is too long?

Definition K. pneumoniae or E. coli Infections K. pneumoniae Infections Alone E. coli Infections Alone
Studies, n [Ref] OR (95% CI) Studies, n [Ref] OR (95% CI) Studies, n [Ref] OR (95% CI)
DAT > 24 h 5 [17, 21, 23, 24, 29] 1.24 (0.85–1.80) 3 [17, 21, 29] 1.37 (0.73–2.54) 4 [17, 21, 23, 24] 1.19 (0.73–1.93)
DAT > 48 h 4 [12, 15, 26, 28] 1.33 (0.84–2.12) 1 [26] a 2 [15, 28] 1.86 (1.23–2.80)
DAT > 72 h 4 [13, 18, 19, 25] 2.12 (0.66–6.79) 2 [13, 19] 1.93 (0.25–12.48) 1 [25] a
DAT > C& SR 7 [11, 14, 16, 20, 22, 27, 30] 2.06 (1.36–3.12) 3 [11, 16, 22] 1.93 (1.29–2.89) 1 [20] a
All (Any DAT > 24 or DAT > C& SR) 20 [11–30] 1.60 (1.25–2.05) 9 [11, 13, 16, 17, 19, 21, 22, 26, 29] 1.53 (1.07–2.17) 8 [15, 17, 18, 20, 21, 23, 24, 28] 1.49 (1.10–2.01)
  1. C& SR culture and susceptibility reporting, DAT delayed appropriate therapy, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, OR odds ratio
  2. aAnalysis not possible owing to the identification of only 1 study with outcomes reported at the indicated time point for delay