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Table 3 OPK activities of mAbs (EC50, ng/ml)

From: Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

  MOPA assay killing Pneumococcal serotypes
Serotype mAb T4 T6b T14 T23f T18c T19f T9v T6a T1 T3 T5 T6c T7F T19A T22F T33F
T4 1A6 29 – – – – – – – ND ND ND ND ND ND ND ND
T4 1A10 55 – – – – – – – ND ND ND ND ND ND ND ND
T4 1B1 23 – – – – – – – ND ND ND ND ND ND ND ND
T18C 1B2 – –   – 47 – – – ND ND ND ND ND ND ND ND
T1 1C6 ND ND ND ND ND ND ND ND 14 – – – – – – –
T7F 1A2 ND ND ND ND ND ND ND ND – – – – 11 – – –
T6a,b 1C4 – 37 – – – – – 100 – – – 142 – – – –
T6a, b 1D7 – 355 – – – – – 334 – – – 2247 – – – –
  1. Note: - = no activity in MOPA assay (EC50 > 7500 ng/ml) [12]. ND = not tested. mAb serotype was determined by ELISA binding
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BMC Infectious Diseases

ISSN: 1471-2334

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