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Table 3 OPK activities of mAbs (EC50, ng/ml)

From: Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

  MOPA assay killing Pneumococcal serotypes
Serotype mAb T4 T6b T14 T23f T18c T19f T9v T6a T1 T3 T5 T6c T7F T19A T22F T33F
T4 1A6 29 ND ND ND ND ND ND ND ND
T4 1A10 55 ND ND ND ND ND ND ND ND
T4 1B1 23 ND ND ND ND ND ND ND ND
T18C 1B2   47 ND ND ND ND ND ND ND ND
T1 1C6 ND ND ND ND ND ND ND ND 14
T7F 1A2 ND ND ND ND ND ND ND ND 11
T6a,b 1C4 37 100 142
T6a, b 1D7 355 334 2247
  1. Note: - = no activity in MOPA assay (EC50 > 7500 ng/ml) [12]. ND = not tested. mAb serotype was determined by ELISA binding