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Table 1 Germline usage analysis for single plasmablast-derived antigen-specific mAbs

From: Human monoclonal antibodies isolated from a primary pneumococcal conjugate Vaccinee demonstrates the expansion of an antigen-driven Hypermutated memory B cell response

Antibody ID Serotype(s) VH    DH JH VL    JL
Family CDR3 Length HCDR3 AA sequence Family Family Family CDR3 length LCDR3 AA sequence Family
1A4 1 3–23*04 10 DVRGSGSNSY 3–10*01 4*02 K2–30*01 9 MQGTYWPPIT KJ2*01
1C6 1 3–53*01 8 EVDYAFDP 3–16*01 5*02 L8–61*01 10 VLFMGSGTWV LJ3*02
1D4 1 3–74*03 8 SASGWYVN 6–19*01 4*02 K4–1*01 9 QHYASVPWT KJ1*01
1A6 6 total 4 3–30-3*01 10 DPDTSNKIDY 2–2*02 4*02 K2–30*01 10 MQGTYWPPIT KJ5*01
1A10 4 3–7*01 10 RMFGSSFRDY 6–6*01 4*02 L2–14*01 10 NSYTSSKTWV LJ3*02
1B1 4 1–46*01 16 GGLLPGVAGATSPFQH 2–2*01 1*01 K3–20*01 9 QRYGSSPVT KJ4*01
1C3 4 3–23*01 12 GPVLPAPKEFDY 2–15*01 4*02 L4–69*01 10 QTWDTVTNWV LJ3*02
1C4 2 total 6A, 6B 3–7*03 8 EEWYRFDY 3–3*02 4*02 L2–8*01 10 SSHAGSKNVI LJ2*01
1D7 6A, 6B 3–7*01 8 EIWFREDY 3–10*01 4*02 L2–8*01 10 GSRVGSNSVV LJ2*01
1A2 7F 3–33*01 14 EPRAIADNYYGMDV 3–3*01 6*02 L10–54*01 11 SAWDSSLNAWV LJ3*02
1B2 2 total 18C 3–7*01 9 LGGWRHLDY 3–16*02 4*02 K1–39*01 9 QQSYSSPYT KJ2*01