Table 1 Characteristics of the trials included in the analysis (N = 47)
Characteristics | No of trials | % |
|---|---|---|
Sponsor | ||
Industry | 30 | 64 |
Academic | 17 | 36 |
Number of centres | ||
Monocentric | 5 | 11 |
Multicentric | 38 | 81 |
Not specified | 4 | 9 |
Country | ||
National | 21 | 45 |
International | 20 | 43 |
Not specified | 6 | 13 |
Location | ||
Community | 8 | 17 |
Hospital | 31 | 66 |
Community and hospital | 1 | 2 |
Blinding of the trial | ||
Simple blind | 2 | 4 |
Double blind | 35 | 74 |
Open-label | 10 | 21 |
Type of trial | ||
Non-inferiority | 23 | 49 |
Superiority | 4 | 9 |
Not specified | 20 | 43 |
Objective of the trial | ||
Antibiotic choice | 32 | 68 |
Antibiotic duration | 5 | 11 |
Other therapeutic strategy | 9 | 19 |
Biomarkers evaluation | 3 | 6 |
Severity score required for inclusion | ||
No | 27 | 57 |
PSIa | 18 | 38 |
CURB 65 | 2 | 4 |