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Table 4 Analysis of associations between IL10-1082A/G, -819C/T and -592C/A polymorphisms and risk of HAM/TSP development

From: Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil

Polymorphisms HAM/TSP AC Crude   
n (%) n (%) OR (IC:95%) p-value Corrected p-value
IL10-1082G/A
 A/A (low) 20 (32.3) 38 (53.5) 1   
 G/A (intermediate) 34 (54.8) 24 (33.8) 2.69 (1.28–5.79)   
 G/G (high) 8 (12.9) 9 (12.7) 1.69 (0.56–5.1) 0.07 0.21
 A/A 20 (32.3) 38 (53.5) 1   
 G/A G/G 42 (67.7) 33 (46.5) 2.42 (1.2–4.97) 0.01 0.07
 Alleles
  A 74 (59.7) 100 (70.4) 1   
  G 50 (40.3) 42 (29.6) 1.61 (0.97–2.70) 0.07 0.21
IL10–819/−592 a
 C/C and C/C 25 (43.3) 29 (40.8) 1   
 C/T and C/A 31 (50.0) 27 (38.0) 1.33 (0.63–2.8)   
 T/T and A/A 6 (9.7) 15 (21.2) 0.46 (0.15–1.33) 0.38 1
 C/C and C/C 25 (40.3) 29 (40.8) 1   
 C/T + T/T and C/A + A/A 37 (59.7) 42 (59.2) 1.02 (0.51–2.05) 1 1
 T/T and A/A 6 (9.7) 15 (21.2) 1   
 C/C + C/T and C/C + C/A 56 (90.3) 56 (78.8) 2.5 (0.94–7.44) 0.12 0.84
Phenotype
 ACC/ACC, ACC/ATA, ATA/ATA (Low) 20 (32.3) 38 (53.5) 1   
 GCC/ACC, GCC/ATA (Intermediate) 34 (54.8) 24 (33.8) 2.69 (1.28–5.79)   
 GCC/GCC (High) 8 (12.9) 9 (12.7) 1.69 (0.56–5.10) 0.07 0.21
  1. HAM/TSP HTLV-1 associated myelopathy tropical spastic paraparesis, Asymptomatic HTLV-1 patients, OR odds ration with confident interval, Chi-square 2 × 2 or 3 × 2 contingent tables, Fisher exact or Cochran-Armitage tests
  2. a-819 and -592 are in linkage disequilibrium