Skip to main content

Table 4 Analysis of associations between IL10-1082A/G, -819C/T and -592C/A polymorphisms and risk of HAM/TSP development

From: Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil

Polymorphisms

HAM/TSP

AC

Crude

  

n (%)

n (%)

OR (IC:95%)

p-value

Corrected p-value

IL10-1082G/A

 A/A (low)

20 (32.3)

38 (53.5)

1

  

 G/A (intermediate)

34 (54.8)

24 (33.8)

2.69 (1.28–5.79)

  

 G/G (high)

8 (12.9)

9 (12.7)

1.69 (0.56–5.1)

0.07

0.21

 A/A

20 (32.3)

38 (53.5)

1

  

 G/A G/G

42 (67.7)

33 (46.5)

2.42 (1.2–4.97)

0.01

0.07

 Alleles

  A

74 (59.7)

100 (70.4)

1

  

  G

50 (40.3)

42 (29.6)

1.61 (0.97–2.70)

0.07

0.21

IL10–819/−592 a

 C/C and C/C

25 (43.3)

29 (40.8)

1

  

 C/T and C/A

31 (50.0)

27 (38.0)

1.33 (0.63–2.8)

  

 T/T and A/A

6 (9.7)

15 (21.2)

0.46 (0.15–1.33)

0.38

1

 C/C and C/C

25 (40.3)

29 (40.8)

1

  

 C/T + T/T and C/A + A/A

37 (59.7)

42 (59.2)

1.02 (0.51–2.05)

1

1

 T/T and A/A

6 (9.7)

15 (21.2)

1

  

 C/C + C/T and C/C + C/A

56 (90.3)

56 (78.8)

2.5 (0.94–7.44)

0.12

0.84

Phenotype

 ACC/ACC, ACC/ATA, ATA/ATA (Low)

20 (32.3)

38 (53.5)

1

  

 GCC/ACC, GCC/ATA (Intermediate)

34 (54.8)

24 (33.8)

2.69 (1.28–5.79)

  

 GCC/GCC (High)

8 (12.9)

9 (12.7)

1.69 (0.56–5.10)

0.07

0.21

  1. HAM/TSP HTLV-1 associated myelopathy tropical spastic paraparesis, Asymptomatic HTLV-1 patients, OR odds ration with confident interval, Chi-square 2 × 2 or 3 × 2 contingent tables, Fisher exact or Cochran-Armitage tests
  2. a-819 and -592 are in linkage disequilibrium