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Table 3 Analysis of associations between TGFB codon 10 T/C and codon 25G/C polymorphisms and risk of HAM/TSP development

From: Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil

Polymorphisms HAM/TSP Asymptomatic   
n (%) n (%) OR (IC:95%) p-value
TGFB Codon 10
 T/T 25 (37.3) 24 (28.9) 1  
 T/C 29 (43.3) 45 (54.2) 0.62 (0.3–1.28)  
 C/C 13 (19.4) 14 (16.9) 0.89 (0.35–2.29) 0.61
 Alleles
  T 79 (59.0) 93 (55.4) 1  
  C 55 (41.0) 73 (43.5) 0.89 (0.56–1.41) 0.70
TGFB Codon 25
 G/G 56 (83.6) 71 (85.5) 1  
 G/C 10 (14.9) 11 (13.3) 1.15 (0.45–2.92)  
 C/C 1 (1.5) 1 (1.2) 1.27 (0.05–32.54) 0.74
 T/C G/G High 47 (70.1) 58 (69.9) 1  
 T/C G/C; C/C G/G; T/T G/C Intermediate 15 (22.4) 24 (28.9) 0.77 (0.36–1.62)  
 C/C G/C; C/C C/C; T/T C/C Low 5 (7.5) 1 (1.2) 6.17 (0.95–120.4) 0.51
  1. HAM/TSP HTLV-1 associated myelopathy tropical spastic paraparesis, Asymptomatic HTLV-1 patients, OR odds ration with confident interval, Chi-square 2 × 2 or 3 × 2 contingent tables, Fisher exact or Cochran-Armitage tests
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BMC Infectious Diseases

ISSN: 1471-2334

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