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Table 2 Analysis of associations between TNFA-308G/A, IL6-174G/C and IFNG + 874 T/A polymorphisms and risk of HAM/TSP development

From: Lack of association between single-nucleotide polymorphisms of pro- and anti-inflammatory cytokines and HTLV-1-associated myelopathy / tropical spastic paraparesis development in patients from Rio de Janeiro, Brazil

Polymorphisms HAM/TSP Asymptomatic   
n (%) n (%) OR (IC:95%) p-value
TNFA-308G/A
 GG 55 (82.1) 69 (83.1) 1 0.98
 GA 12 (17.9) 13 (15.7) 1.16 (0.48–2.75)  
 AA 0 1 (1.2) 0 (NA)  
 GG (low) 55 (82.1) 69 (83.1) 1 1
 GA + AA (high) 12 (17.9) 14 (16.9) 1.08 (0.45–2.52)  
 AA 0 1 (1.2) 1 1
 GA + GG 67 (100) 82 (98.8) 0 (NA)  
Alleles
  G 122 (91.0) 151 (91.0) 1 1
  A 12 (9.0) 15 (9.0) 0.99 (0.44–2.19)  
IL6-174G/C
 GG 48 (71.6) 56 (68.3) 1 0.88
 GC 16 (23.9) 24 (29.3) 0.78 (0.37–1.62)  
 CC 3(4.5) 2 (2.4) 1.75 (0.28–13.7)  
 CC (low) 3 (4.5) 2 (2.4) 1 0.66
 GC + GG (high) 64 (95.5) 80 (97.6) 0.53 (0.07–3.31)  
 GG 48 (71.6) 56 (68.3) 1 0.79
 GC + CC 19 (28.4) 26 (31.7) 0.85 (0.42–172)  
Alleles
  G 112(83.6) 136 (82.9) 1 1
  C 22 (16.4) 28 (17.1) 0.95 (0.51–1.76)  
IFNG + 874 T/A
 AA (low) 34 (50.7) 34 (43.6) 1 0.86
 AT (intermediate) 26 (38.8) 40 (51.3) 0.65 (0.33–1.29)  
 TT (high) 7(10.4) 4 (5.1) 1.75 (0.48–7.20)  
 AA 34 (50.7) 34 (43.6) 1 0.49
 AT+TT 33 (49.3) 44 (56.4) 0.75 (0.39–1.44)  
 TT 7 (10.4) 4 (5.1) 1 0.35
 AT+AA 60 (89.6) 74 (94.9) 0.46 (0.12–1.61)  
Alleles
  A 94 (70.1) 108 (69.2) 1 0.97
  T 40 (29.9) 48 (30.8) 0.96 (0.58–1.58)  
  1. HAM/TSP HTLV-1 associated myelopathy tropical spastic paraparesis, Asymptomatic HTLV-1 patients, OR odds ration with confident interval, Chi-square 2 × 2 or 3 × 2 contingent tables, Fisher exact or Cochran-Armitage tests