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Table 4 SNPs between Isolates from Epidemiologically Identified Clusters

From: Genomic sequencing is required for identification of tuberculosis transmission in Hawaii

U Cluster 1
  47 54 57 83 55
47 X
54 23 X
57 117 120 X
83 1 24 118 X
55 1 24 118 0 X
Mixed Cluster 1
  63 65 86   
63 X     
65 1761 X    
86 0 1762 X   
  1. Matrix displaying the number of SNPs between each pair of isolates from two epidemiologically identified clusters. Isolate 55 (italicized) from Mixed Cluster 2 was added to U Cluster 1 for comparison due to having an identical spoligotype and MIRU-VNTR fingerprint. With only a single SNP separating isolates 55 and 83 from isolate 47, but a larger number of SNPs separating those isolates from isolates 54 and 57, this cluster includes both direct transmission and non-linked isolates. The presence of zero SNPs between isolates 63 and 86 from Mixed Cluster 1 indicates direct transmission. The presence of more than 12 SNPs between isolates 63 and 65 or 65 and 86 indicates that direct transmission between them can be ruled out. This confirms the expected result indicated by their different spoligotyping lineages