| |
First sample
|
Second sample
|
|---|
|
TB, n(%)
|
Controls, n(%)
|
ORa (95% CI)
|
Pa
|
PTB, n(%)
|
LTBI, n (%)
|
ORb (95% CI)
|
Pb
|
LTBI, n(%)
|
HC, n (%)
|
ORb (95% CI)
|
Pb
|
|---|
|
Genotype
|
|
GG
|
75 (12.9)
|
74 (12.3)
|
1.07 (0.74–1.55)
|
0.70
|
41 (19.6)
|
29 (14.5)
|
1.80 (0.99–3.27)
|
0.06
|
29 (14.5)
|
30 (14.8)
|
0.83 (0.46–1.52)
|
0.55
|
|
GA
|
267 (46.0)
|
271 (44.9)
|
1.06 (0.83–1.36)
|
0.64
|
93 (44.5)
|
71 (35.5)
|
1.68 (1.07–2.65)
|
0.03
|
71 (35.5)
|
93 (45.8)
|
0.64 (0.41–0.98)
|
0.04
|
|
AA
|
238(41.0)
|
259 (42.9)
|
1
|
Reference
|
75 (35.9)
|
100 (50.0)
|
1
|
Reference
|
100 (50.0)
|
80 (39.4)
|
1
|
Reference
|
|
Allele
|
|
G
|
417 (35.9)
|
419 (34.7)
|
1.05 (0.88–1.24)
|
0.6
|
175 (41.9)
|
129 (32.3)
|
1.48(1.10–2.00)
|
0.01
|
129 (32.3)
|
153 (37.7)
|
0.82 (0.61–1.10)
|
0.19
|
|
A
|
743 (64.1)
|
789 (65.3)
|
1
|
Reference
|
243 (58.1)
|
271 (67.8)
|
1
|
Reference
|
271 (67.8)
|
253 (62.3)
|
1
|
Reference
|
|
Dominant
|
|
GG + GA
|
342 (59.0)
|
345 (57.1)
|
1.07 (0.85–1.35)
|
0.59
|
134 (64.1)
|
100 (50.0)
|
1.70 (1.12–2.57)
|
0.01
|
100 (50.0)
|
123 (60.6)
|
0.68 (0.46–1.02)
|
0.06
|
|
AA
|
238 (41.0)
|
259 (42.9)
|
1
|
Reference
|
75 (35.9)
|
100 (50.0)
|
1
|
Reference
|
100 (50.0)
|
80 (39.4)
|
1
|
Reference
|
|
Recessive
|
|
GG
|
75 (12.9)
|
74 (12.3)
|
1.05 (0.74–1.48)
|
0.8
|
41 (19.6)
|
29 (14.5)
|
1.40 (0.81–2.42)
|
0.22
|
29 (14.5)
|
30 (14.8)
|
1.03 (0.59–1.79)
|
0.93
|
|
GA + AA
|
505 (87.1)
|
530 (87.7)
|
1
|
Reference
|
168 (80.4)
|
171 (85.5)
|
1
|
Reference
|
171 (85.5)
|
173 (85.2)
|
1
|
Reference
|
- Abbreviations: TB tuberculosis, PTB pulmonary tuberculosis, LTBI latent tuberculosis infection, HC healthy control, a, adjusted for age, gender and smoking with logistic regression; b, adjusted for age and gender with logistic regression; OR, odds ratio; CI, confidence interval
