Table 4 Association between rs187084 and TB, LTBI and PTB susceptibility in Chinese Han population
| Â | First sample | Second sample | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
TB, n(%) | Controls, n(%) | ORa (95% CI) | Pa | PTB, n(%) | LTBI, n (%) | ORb (95% CI) | Pb | LTBI, n(%) | HC, n (%) | ORb (95% CI) | Pb | |
Genotype | ||||||||||||
 GG | 75 (12.9) | 74 (12.3) | 1.07 (0.74–1.55) | 0.70 | 41 (19.6) | 29 (14.5) | 1.80 (0.99–3.27) | 0.06 | 29 (14.5) | 30 (14.8) | 0.83 (0.46–1.52) | 0.55 |
 GA | 267 (46.0) | 271 (44.9) | 1.06 (0.83–1.36) | 0.64 | 93 (44.5) | 71 (35.5) | 1.68 (1.07–2.65) | 0.03 | 71 (35.5) | 93 (45.8) | 0.64 (0.41–0.98) | 0.04 |
 AA | 238(41.0) | 259 (42.9) | 1 | Reference | 75 (35.9) | 100 (50.0) | 1 | Reference | 100 (50.0) | 80 (39.4) | 1 | Reference |
Allele | ||||||||||||
 G | 417 (35.9) | 419 (34.7) | 1.05 (0.88–1.24) | 0.6 | 175 (41.9) | 129 (32.3) | 1.48(1.10–2.00) | 0.01 | 129 (32.3) | 153 (37.7) | 0.82 (0.61–1.10) | 0.19 |
 A | 743 (64.1) | 789 (65.3) | 1 | Reference | 243 (58.1) | 271 (67.8) | 1 | Reference | 271 (67.8) | 253 (62.3) | 1 | Reference |
Dominant | ||||||||||||
 GG + GA | 342 (59.0) | 345 (57.1) | 1.07 (0.85–1.35) | 0.59 | 134 (64.1) | 100 (50.0) | 1.70 (1.12–2.57) | 0.01 | 100 (50.0) | 123 (60.6) | 0.68 (0.46–1.02) | 0.06 |
 AA | 238 (41.0) | 259 (42.9) | 1 | Reference | 75 (35.9) | 100 (50.0) | 1 | Reference | 100 (50.0) | 80 (39.4) | 1 | Reference |
Recessive | ||||||||||||
 GG | 75 (12.9) | 74 (12.3) | 1.05 (0.74–1.48) | 0.8 | 41 (19.6) | 29 (14.5) | 1.40 (0.81–2.42) | 0.22 | 29 (14.5) | 30 (14.8) | 1.03 (0.59–1.79) | 0.93 |
 GA + AA | 505 (87.1) | 530 (87.7) | 1 | Reference | 168 (80.4) | 171 (85.5) | 1 | Reference | 171 (85.5) | 173 (85.2) | 1 | Reference |