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Table 4 Test characteristics of the Biocentric platform (both laboratories combined) after re-quantification of discordant VL samples

From: Field suitability and diagnostic accuracy of the Biocentric® open real-time PCR platform for plasma-based HIV viral load quantification in Swaziland

 

At 2.62 log10 copies/mL

(n = 364)

At 3.0 log10 copies/mL

(n = 364)

Sensitivity

% (95% CI)

93.5 (85.5–97.9)

97.1 (90.1–99.7)

Specificity

% (95% CI)

98.6 (96.5–99.6)

99.0 (97.0–99.8)

ROC area

% (95% CI)

0.96 (0.93–0.99)

0.98 (0.96–1.0)

PPV (at 10%)a

% (95% CI)

88.2 (73.8–95.2)

91.4 (77.4–97.0)

NPV (at 10%)a

% (95% CI)

99.3 (98.3–99.7)

99.7 (98.8–99.9)

PPV (at 20%)a

% (95% CI)

94.4 (86.4–97.8)

96.0 (88.5–98.7)

NPV (at 20%)a

% (95% CI)

98.4 (96.3–99.3)

99.3 (97.2–99.8)

  1. If VL re-quantification was not feasible, the first VL testing result was taken into account
  2. ROC Receiver operating characteristic, PPV Positive predictive value, NPV Negative predictive value
  3. aFor the calculation of predictive values, 10 and 20% prevalence of detectable VLs were assumed in a hypothetical population undergoing routine VL testing
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BMC Infectious Diseases

ISSN: 1471-2334

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