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Table 1 Characteristics of patients with HBV-related liver disease segregated according to clinical status

From: Soluble fibrinogen-like protein 2 levels in patients with hepatitis B virus-related liver diseases

Characteristics

AHB (n = 29)

CHB (n = 73)

LC (n = 70)

HCC (n = 99)

LC + HCC (n = 25)

HC (n = 158)

P value

Age (median, range)

32 (17–70)

39.5 (20–76)

48 (17–74)

50 (15–79)

56 (37–81)

31 (19–38)

<  0.001

Gender (male/female)

23/6

55/18

54/16

84/15

25/0

112/46

<  0.001

Liver cirrhosis stage:

 Child-Pugh A (n,%)

NA

NA

22 (49%)a

NA

15 (60%)

NA

NA

 Child-Pugh B (n,%)

NA

NA

12 (28%)a

NA

8 (32%)

NA

NA

 Child-Pugh C (n,%)

NA

NA

10 (23%)a

NA

2 (8%)

NA

NA

RBC (×103/ml)

NA

6.7 (4.5–13.9)

6 (2.7–20.5)

5.8 (4–11)

5.7 (2.7–11)

NA

<  0.01

WBC (× 106/ml)

NA

4.9 (4.1–5.3)

4.3 (2.3–6.7)

4.9 (4.2–6)

4.5 (3–6)

NA

<  0.001

PLT (×103/ml)

NA

168.5 (61–355)

87.5 (49–299)

196 (101–361)

122 (35–237)

NA

<  0.001

AST (IU/L)

1109 (115.5–4593)

143 (77–657)

71 (16.8–1059)

67 (14–371)

63 (25–655)

NA

<  0.001

ALT (IU/L)

861.5 (182–4425)

144 (89–1643)

57 (8–1426)

50.5 (3–471)

54 (22–551)

NA

<  0.001

Total-Bilirubin (mg/dl)

132 (21.8–558)

22.5 (12–412)

30.3 (6.5–722)

19 (5.1–282)

23 (9–185)

NA

<  0.001

Direct-Bilirubin (mg/dl)

117.3 (14.3–512)

12.4 (6.2–292.3)

14 (1.3–450)

8.8 (2–189.4)

8 (2–59)

NA

<  0.001

Albumin (g/L)

NA

42 (33–50)

32.5 (25–39)

39 (30–47)

38 (27–44)

NA

<  0.01

Prothrombin (%)

85 (50–120)

76 (26–122)

46 (15–100)

78 (37–100)

77 (19.6–117)

NA

<  0.01

HBV-DNA (log10 copies/ml)

3.96 (3.5–5.7)

4.2 (2.8–4.66)

4.1 (2.8–6.4)

3.98 (2.5–8.9)

6 (2.3–10.4)

NA

<  0.001

Alpha fetoprotein (IU/L)

NA

12.5 (2–151)

6.7 (1.2–1050)

96.7 (1.5–1050)

113 (2–300)

NA

<  0.001

  1. Abbreviations: AHB acute hepatitis B, CHB chronic hepatitis B, LC liver cirrhosis, HCC hepatocellular carcinoma, LC + HCC patients with both LC and HCC, HC healthy control, RBC red blood cells, WBC white blood cells, PLT platelets, AST and ALT aspartate and alanine amino transferase, AFP alpha-fetoprotein, IU international unit, NA not applicable. Values given are medians and ranges. P values were calculated by Chi-squared test and Kruskal-Wallis test where appropriate. aOnly patients with clear classification and Child-Pugh score available