2010
|
iPrEx [6]
|
Global
|
MSM/TGW
|
Daily
|
51
|
9
|
95
|
> 90
|
–
|
2012
|
Partners study [7]
|
Kenya and Uganda
|
Heterosexual HIV-discordant couples
|
Daily
|
82
|
31
|
–
|
92
|
–
|
2012
|
TDF2 [8]
|
Botswana
|
Heterosexual
|
Daily
|
80
|
50
|
94
|
84
|
–
|
2012
|
FEM-PrEP [13]
|
Kenya, Tanzania, South Africa
|
Heterosexual females
|
Daily
|
24
|
15
|
95
|
88
|
–
|
2012
|
Kenya safety and adherence study [38]
|
Kenya
|
MSM and female sex workers
|
Daily
|
–
|
–
|
–
|
–
|
83% (IQR 63 to 92)
|
Time-driven
|
100
|
55 (pre-coital), 26 (post-coital)
|
2013
|
Partners adherence substudy [17]
|
Kenya and Uganda
|
Heterosexual HIV-discordant couples
|
Daily
|
–
|
–
|
–
|
99
|
97
|
2013
|
Bangkok tenofovir study [31]
|
Bangkok
|
PWID
|
Daily
|
67
|
39
|
94
|
–
|
–
|
2013
|
Uganda safety and adherence study [35]
|
Uganda
|
Heterosexual HIV-discordant couples
|
Daily
|
–
|
–
|
–
|
97
|
Time-driven
|
100
|
91 (pre-coital) 45 (post-coital)
|
2013
|
ATN 082 (Project PrEPARE) [54]
|
United States
|
Young MSM
|
Daily
|
20
|
62
|
–
|
–
|
2014
|
iPrEx extension [15]
|
Global
|
MSM/TGW
|
Daily
|
71
|
85 c
|
–
|
–
|
2015
|
VOICE [14]
|
South Africa, Uganda, Zimbabwe
|
Heterosexual females
|
Daily
|
29supp
|
87 (via computer), 90 (face to face)
|
88
|
–
|
30
|
87 (via computer), 91 (face to face)
|
84
|
2015
|
Generating adherence Philadelphia [50]
|
United States
|
Young MSM of colour
|
Daily
|
–
|
–
|
72
|
–
|
2015
|
HPTN 067/ADAPTa [36]
|
South Africa
|
Heterosexual females
|
Daily
|
68
|
–
|
–
|
76
|
Time-driven
|
56
|
65
|
Event-driven
|
53
|
53
|
2015
|
PROUD [9]
|
United Kingdom
|
MSM
|
Daily
|
100 c
|
–
|
–
|
–
|
2015
|
IPERGAY [10]
|
France and Canada
|
MSM/TGW
|
Event-driven
|
87
|
0
|
29 (suboptimal), 43 (optimal) b
|
–
|
–
|
2016
|
Bangkok MSMa [55]
|
Thailand
|
MSM/TGW
|
Daily
|
–
|
9.8 (complete adherence)
|
–
|
–
|
2016
|
Permanente Cohort [24]
|
USA
|
At-risk
|
Daily
|
–
|
–
|
92
|
–
|
2016
|
The Demo Project [23]
|
USA
|
MSM/TGW
|
Daily
|
80 d
|
–
|
82
|
–
|
2017
|
SPARKa [57]
|
United States
|
MSM
|
Daily
|
90
|
–
|
–
|
–
|
2017
|
IPERGAY extension [22]
|
France/Canada
|
MSM/TGW
|
Event-driven
|
71 e
|
0
|
24 (suboptimal), 50 (optimal)
|
–
|
–
|
2017
|
Short term PrEP Mozambiquea [25]
|
Mozambique
|
Heterosexual females
|
Daily
|
76
| | |
–
|
2017
|
Parisian MSMa [26]
|
France
|
MSM
|
Daily & Event-driven
|
83
|
–
|
–
|
–
|
2017
|
PRELUDEa [27, 28]
|
Australia
|
Gay/bisexual males
|
Daily
|
51 d
|
–
|
–
|
–
|
2017
|
PROUD adherencea [29]
|
UK
|
MSM
|
Daily
|
–
|
98
|
–
|
–
|
2017
|
Pluspillsa [30]
|
South Africa
|
Adolescents
|
Daily
|
38
|
–
|
92
|
–
|
2017
|
Brazil Demoa [65]
|
Brasil
|
MSM/TGW
|
Daily
|
74
|
–
|
–
|
–
|