2010
|
iPrEx [6]
|
Global
|
MSM/TGW
|
2499
|
3324
|
RDBPCT
|
Daily
|
TDF-FTC
|
36
|
64
|
100
|
2012
|
Partners study [7]
|
Kenya and Uganda
|
Heterosexual HIV-discordant couples
|
4758
|
7820
|
RDBPCT
|
Daily
|
TDF-FTC
|
13
|
52
|
82
|
TDF
|
17
|
2012
|
TDF2 [8]
|
Botswana
|
Heterosexual
|
1219
|
1563
|
RDBPCT
|
Daily
|
TDF-FTC
|
9
|
24
|
33
|
2012
|
FEM-PrEP [13]
|
Kenya, Tanzania and South Africa
|
Heterosexual females
|
2120
|
–
|
RDBPCT
|
Daily
|
TDF-FTC
|
33
|
35
|
68
|
2012
|
Kenya safety and adherence study [38]
|
Kenya
|
MSM and Female sex workers
|
72
|
–
|
RDBPCT
|
Daily
|
TDF-FTC
|
0
|
1
|
1
|
Time-driven
|
0
|
2013
|
Partners adherence substudy [17]
|
Kenya and Uganda
|
Heterosexual HIV-discordant couples
|
1147
|
807
|
Convenience sub-cohort of a RDBPCT
|
Daily
|
TDF-FTC
|
0
|
14
|
14
|
TDF
|
0
|
2013
|
Bangkok tenofovir study [31]
|
Bangkok
|
PWID
|
2413
|
9665
|
RDBPCT
|
Daily
|
TDF
|
17
|
33
|
50
|
2013
|
Uganda safety and adherence study [35]
|
Uganda
|
Heterosexual HIV-discordant couples
|
72
|
–
|
RDBPCT
|
Daily
|
TDF-FTC
|
0
|
0
|
0
|
Time-driven
|
0
|
0
|
2013
|
ATN 082 (Project PrEPARE) [54]
|
United States
|
Young MSM
|
58
|
–
|
RBPCT
|
Daily
|
TDF-FTC
|
0
|
0
|
0
|
No pill
|
0
|
2014
|
iPrEx extension [15]
|
Global
|
MSM/TGW
|
1603 (1225 received)
|
–
|
Open Label
|
Daily
|
TDF-FTC
|
28
|
13
|
41
|
2015
|
VOICE [14]
|
South Africa, Uganda, Zimbabwe
|
Heterosexual females
|
3019
|
4253
|
RCT
|
Daily
|
TDF-FTC
|
61
|
60
|
173
|
TDF
|
52
|
2015
|
HPTN 067/ADAPTa [36]
|
South Africa
|
Heterosexual females
|
191
|
–
|
RCT with different regimens as comparators
|
Daily
|
TDF-FTC
|
1
|
N/A
|
5
|
Time-driven
|
2
|
Event-driven
|
2
|
2015
|
Generating adherence Philadelphia [50]
|
United States
|
Young MSM of colour
|
23
|
7.5
|
Observational
|
Daily
|
TDF-FTC
|
0
|
N/A
|
0
|
2015
|
PROUD [9]
|
United Kingdom
|
MSM
|
544
|
465
|
RCT with a 1 year deferred group as comparator
|
Daily
|
TDF-FTC
|
3
|
20
|
23
|
2015
|
IPERGAY [10]
|
France and Canada
|
MSM/TGW
|
400
|
431
|
RDBPCT
|
Event-driven
|
TDF-FTC
|
2
|
14
|
16
|
2016
|
Bangkok MSMa [55]
|
Thailand
|
MSM /TGW
|
168
|
–
|
Observational
|
Daily
|
TDF-FTC
|
0
|
N/A
|
0
|
2016
|
Permanente Cohort [24]
|
USA
|
At-risk
|
972
|
850
|
Open label
|
Daily
|
TDF-FTC
|
0
|
2 Off-PrEP
|
2
|
2016
|
The Demo Project [23]
|
USA
|
MSM/TGW
|
557
|
481
|
Open label
|
Daily
|
TDF-FTC
|
1
|
1 Off-PrEP
|
2
|
2017
|
SPARKa [57]
|
United States
|
MSM
|
301
|
–
|
Open Label
|
Daily
|
TDF-FTC
|
–
|
–
|
–
|
2017
|
IPERGAY extension [22]
|
France/Canada
|
MSM/TGW
|
361
|
518
|
Open label
|
Event-driven
|
TDF-FTC
|
0
|
1 Off-PrEP
|
1
|
2017
|
Short term PrEP Mozambiquea [25]
|
Mozambique
|
Heterosexual females
|
74
|
7.4
|
Open label
|
Daily
|
TDF-FTC
|
0
|
N/A
|
1
|
2017
|
Parisian MSMa [26]
|
France
|
MSM
|
785
|
215
|
Open label
|
Daily & Event-driven
|
TDF-FTC
|
3
|
N/A
|
3
|
2017
|
PRELUDEa [27, 28]
|
Australia
|
Gay/bisexual males
|
317
|
381
|
Open label
|
Daily
|
TDF-FTC
|
0
|
N/A
|
0
|
2017
|
PROUD adherencea [29]
|
UK
|
MSM
|
544 enrolled (481 initiated)
|
1253
|
Open label
|
Daily
|
TDF-FTC
|
10
|
N/A
|
10
|
2017
|
Pluspillsa [30]
|
South Africa
|
Adolescents
|
148
|
131
|
Open label
|
Daily
|
TDF-FTC
|
0
|
1 Off-PrEP
|
1
|
2017
|
Brazil Demoa [65]
|
Brasil
|
MSM/TGW
|
450
|
389
|
Open label
|
Daily
|
TDF-FTC
|
0
|
2 Off-PrEP
|
2
|