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Table 4 Univariate and multivariate analysis of factors associated with 1-year mortality among 44 cryptococcal meningitis patients

From: High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

Factor Univariate Analysis Multivariate Analysis
Total No. of patients No. (%) of patients who died P-valueb P-value RR (95% CI)
Age ≥ 60 years 12 4 (33.3) 0.022   
Initial AmB course < 6 weeks 10 3 (30.0) 0.095   
Salvage therapy without 5FC 13 3 (23.1) 0.196   
Serum albumin level < 35 g/L 13 5 (38.5) 0.001 0.014 16.23 (1.78–148.19)
eGFR < 60 mL/min/1.73m2 8 3 (37.5) 0.015   
CSF WBC count < 10 /mm3a 14 4 (28.6) 0.012   
CSF glucose level < 36 mg/dLa 22 1 (4.5) 0.127   
CSF CrAg titer ≥ 1280a 17 4 (23.5) 0.058 0.048 9.30 (1.02–84.73)
  1. AmB Amphotericin B; 5FC flucytosine; eGFR estimated glomerular filtration rate; CrAg cryptococcal capsular antigen; CSF cerebrospinal fluid; WBC white blood cell
  2. aData of CSF WBC count, CSF glucose level and CSF cryptococcal antigen titter was unavailable in 1 dead patient
  3. bFactor entered the initial univariate analysis included male, age ≥ 60 years, time before diagnosis ≥60 days, predisposing factors, pulmonary involvement, seizure, altered mental status, parenchyma lesions of brain MRI, initial AmB course < 6 weeks, salvage therapy without 5FC, serum albumin level < 35 g/L, eGFR < 60 mL/min/1.73m2, CSF WBC count < 10 /mm3, CSF protein level > 500 mg/dL, CSF glucose level < 36 mg/dL, CSF CrAg titer ≥1280. Only predictors with a P-value less than 0.2 were listed in the table