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Table 1 Baseline characteristics, signs and symptoms of 44 cryptococcal meningitis patients treated with high dose fluconazole for salvage therapy

From: High dose fluconazole in salvage therapy for HIV-uninfected cryptococcal meningitis

Variables No. (%) of patients
Sex, male 28 (63.6)
Age, years 44 (range, 16–73)
Predisposing factors
 Evans syndrome 4 (9.1)
 MDS 1 (2.3)
 ITP 1 (2.3)
 Lymphoma 1 (2.3)
 Solid tumora 2 (4.5)
 SLE 5 (11.4)
 Cirrhosis 2 (4.5)
 Liver transplantation 1 (2.3)
 Splenectomy 1 (2.3)
 Type 2 diabetes mellitus 2 (4.5)
 Steroids or immunosuppressants 10 (22.7)
Headache 44 (100)
Fever 32 (72.7)
Vomiting 32 (72.7)
Meningeal irritation 32 (72.7)
Seizure 16 (36.4)
Altered mental statusb 12 (27.3)
Cranial nerve defect
 Impaired vision 16 (36.4)
 Diplopia 8 (18.2)
 Visual field defect 8 (18.2)
 Ophthalmodynia 3 (6.8)
 Hearing impairment 18 (40.9)
 Facial paralysis 3 (6.8)
Limb weakness 14 (31.8)
uracratia 3 (6.8)
Dysuria 3 (6.8)
  1. MDS myelodysplastic syndrome; SLE systemic lupus erythematosus; ITP idiopathic thrombocytopenia
  2. aIncluding 1 gastric cancer and 1 cholangiocellular carcinoma
  3. bPatients with scores less than 15 by Glasgow Coma Scale