Factor | Proportion | Case fatality rate | Unadjusted odds ratios (95%CI) for case fatality | P values |
---|---|---|---|---|
Age (yrs) | ||||
≤ 40 years old | 122/393 (31%) | 27 (22.1%) | 1 | |
41–55 years old | 152/393 (38.7%) | 46 (30.3%) | 1.527 (0.881–2.646) | 0.131 |
≥ 56 years old | 119/393 (30.3%) | 37 (31.1%)_ | 1.588 (0.891–2.828) | 0.117 |
Male sex (%) | 271/393 (69.0%) | 84 (31.0%) | 1.659 (1.002–2.746) | 0.049 |
Any previous hospitalisation (%) | 150/393 (38.2%) | 62 (41.3%) | 2.862 (1.819–4.503) | < 0.001 |
Any antibiotic prior to NHTD hospitalisation (%) | 50/150 (33.3%) | 23 (46.0%) | 1.332 (0.671–2.646) | 0.412 |
Time from onset to current hospitalisation < 5 days | 217/393 (55.2%) | 57 (26.3%) | 0.827 (0.532–1.286) | 0.399 |
Direct ICU admission | 145/393 (36.9%) | 68 (46.9%) | 4.331 (2.720–6.898) | < 0.001 |
Any history of medical disease | 106/393 (27.0%) | 44 (41.5%) | 2.376 (1.479–3.818) | < 0.001 |
HIV | 19/393 (4.8%) | 10 (52.6%) | 3.044 (1.202–7.710) | 0.019 |
Moderate or severe liver disease | 53/393 (13.5%) | 25 (47.2%) | 2.679 (1.481–4.844) | 0.001 |
Diabetes | 25/393 (6.4%) | 7 (28.0%) | 1.001 (0.406–2.466) | 0.999 |
Concurrent foci of infection | ||||
Radiology-confirmed pneumonia on admission | 98/393 (24.9%)a | 29 (29.6%) | 1.11 (0.671–1.837) | 0.684 |
Lumbar puncture confirmed meningitis on admission | 72/393 (18.3%)b | 19 (26.4%) | 0.906 (0.509–1.614) | 0.738 |
Heart valve vegetations during hospitalisation | 16/393 (4.1%) | 4 (25.0%) | 0.852 (0.269–2.701) | 0.786 |
Any abscess during hospitalisation | 33/393 (8.4%)c | 6 (18.2%) | 0.547 (0.219–1.364) | 0.196 |
Organ dysfunction on admission | ||||
Cardiovascular | 65/393 (16.5%) | 52 (80.0%) | 18.621 (9.522–36.415) | < 0.001 |
Respiratory | 87/393 (22.1%) | 53 (60.9%) | 6.81 (4.057–11.431) | < 0.001 |
CNS | 105/393 (26.7%) | 55 (52.4%) | 4.66 (2.876–7.551) | < 0.001 |
Hepatic | 146/393 (37.2%) | 57 (39.0%) | 2.344 (1.494–3.678) | < 0.001 |
Renal | 153/393 (38.9%) | 66 (43.1%) | 3.379 (2.139–5.339) | < 0.001 |
Coagulation | 226/393 (57.5%) | 85 (37.6%) | 3.424 (2.070–5.663) | < 0.001 |