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Table 1 Clinical findings and laboratory data of the two patients with SFTS who presented with reactive plasmacytosis

From: Reactive plasmacytosis mimicking multiple myeloma associated with SFTS virus infection: a report of two cases and literature review

Gender/age,y

M/63

F/42

Occupation

farmer

farmer

Onset to admission, d

8

7

Tick bite history

+

+

Fever

+

+

Gastrointestinal symptomsa

+

+

Lymphadenopathy

+

+

Rash

+

+

Fatigue

+

_

hemorrhageb

_

+

Apathy

_

+

WBC (3.5–9.5a10~ 9/L)

24.46

2.58

RBC(M: 4.3–5.8a10~ 12/L, F: 3.8–5.1a10~ 12/L)

3.86

4.03

PLT(125–350a10~ 9/L)

75

25

PT(11.0–13.7 s)

16.9

17.5

Fg(2.00–4.00 g/L)

2.9

1.82

APTT(31.5–43.5 s)

68.3

90.0

Proteinuria

1+

microscale

AMY(28–100 U/L)

30

230

LPS(13–60 U/L)

27

194

ALT(13–69 U/L)

37

727

AST(15–46 U/L)

28

2940

ALP(38–126 U/L)

244

120

LDH(135–225 U/L)

794(313–618 U/L)

2690

CK(39–308 U/L)

21

1086

Immunofixation electrophoresis

polyclonal IgG

polyclonal IgG

IgA(0.82–4.53 g/L)

2.64

2.43

IgG(7.51–15.6 g/L)

17.2

28.5

IgM(0.46–3.04 g/L)

28.1

0.76

Antibody IgM, RNA of SFTSV

+

+

Bone marrow cytology

Plasma cells accounting for 29.2%: naïve (6.8%) and mature (22.4%) ones.

(2014-7-18) Plasma cells accounting for 50.4%: naïve (39.6%) and mature (10.8%); (2014-7-31) normal mature plasma cells accounting for 2.2%, no naive plasma cells.

Flow cytometric immunophenotyping(FCI)

Plasma cells of normal phenotype accounting for 20%, mainly expressing CD38, CD 138, CD19; partly expressing CD 200, cKappa, and cLambda, not expressed CD20, Kappa, Lambda, CD25, CD35, CD22, FMC7, CD103, CD10, CD5, IgM, CD23, CD117, and CD56.

(2014-7-18) Plasma cells of abnormal phenotype accounting for 44.7%, mainly expressing CD38, CD 138, CD19, and cLambda; not expressing CD7, CD117, CD33, CD10, CD34, CD28, CD56, CD25, CD11c, CD5, FMC7, CD22, TdT, CD200, CD20, Kappa, Lambda, and cKappa.

(2014-7-31) Plasma cells of normal phenotype accounting for 1.1%, mainly expressing CD38, CD138, CD19, partly expressing cKappa and cLambda.

outcome

Recoverd

Recoverdc

  1. a Nausea, vomiting, anorexia, or abdominal discomfort
  2. b Multiple skin petechiae or ecchymosis
  3. c This patient was diagnosed with angioimmunoblastic T-cell lymphoma 8 months later and died eventually