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Table 1 Characteristics of the enrolled patients overall and by length of treatment (group A: treatment lasting for 3 months and group B: treatment lasting for 6 months)

From: Evaluation of cardiac function by global longitudinal strain before and after treatment with sofosbuvir-based regimens in HCV infected patients

Variable

Total n (%)

Group A

n (%)

Group B

n (%)

p-value

Gender

 Male

46 (56.1)

35 (61.4)

11 (44)

 

 Female

36 (43.9)

22 (38.6)

14 (56)

0.144

Age (years)

  ≤ 60

22 (26.8)

17 (29.8)

5 (20)

 

 61–68

22 (26.8)

16 (28.1)

6 (24)

 

 69–74

24 (29.3)

15 (26.3)

8 (32)

 

  ≥ 75

14 (17.1)

9 (15.8)

6 (24)

0.666

Type of liver disease

 No cirrhosis or HCC

45 (54.9)

34 (59.6)

9 (36)

 

 Cirrhosis

35 (42.7)

23 (40.4)

14 (56)

 

 HCC with cirrhosis

2 (2.4)

0 (0)

2 (8)

0.025

Transient elastography

 None

7 (8.5)

   

 F0

0 (0)

0 (0)

0 (0)

 

 F1

2 (2.4)

2 (3.9)

0 (0)

 

 F2

3 (3.8)

3 (5.9)

0 (0)

 

 F3

33 (40.2)

29 (56.9)

3 (13)

 

 F4

37 (45.1)

17 (33.3)

20 (87)

< 0.01

HCV Genotype

 1a

2 (2.4)

1 (1.7)

1 (4)

 

 1b

60 (73.3)

42 (73.7)

17 (68)

 

 2

6 (7.3)

3 (5.3)

3 (12)

 

 2a/2c

5 (6.1)

6 (10.5)

0 (0)

 

 3

4 (4.8)

1 (1.7)

3 (12)

 

 4

5 (6.1)

4 (7.1)

1 (4)

0.148

Co-infections

 None

81 (98.8)

56 (98.3)

25 (100)

 

 HIV +

1 (1.2)

1 (1.7)

0 (0)

 

 HBsAg +/HIV -

0 (0)

0 (0)

(0)

0.505

BMI

 Normal

23 (28)

18 (31.6)

5 (20)

 

 Overweight/Obese

59 (71.0)

39 (68.4)

20 (80)

0.283

Risk factors for CV diseasesa

 None

19 (23.2)

15 (26.3)

4 (16)

0.308

 Hypertension

51 (62.2)

34 (59.6)

17 (68)

0.473

 Diabetes mellitus

21 (25.6)

12 (21.1)

8 (32)

0.288

 Smoking habits

14 (17.1)

11 (19.3)

3 (12)

0.419

 Previous CV events

4 (4.8)

3 (5.3)

1 (4)

0.807

Comorbiditiesa

 None

19 (23.2)

15 (26.3)

4 (16)

0.308

 eGFR < 90 ml/min

43 (52.4)

32 (39)

11 (13.4)

0.350

 Osteoporosis

15 (18.3)

10 (17.6)

5 (20)

0.791

 Depression

14 (17.1)

11 (19.3)

3 (12)

0.419

  1. aEach patient may have more than one risk factors and comorbidities
  2. CV Cardiovascular, eGFR Estimated glomerular filtrate rate