Oseltamivir in pregnancy and birth outcomes

BMC Infectious Diseases

Table 5 Exposure to oseltamivir in pregnancy and spontaneous or induced abortions

Type of abortion	Exposed^a		Unexposed		Crude hazard ratio (95% CI)	Adjusted^b hazard ratio (95% CI)
Spontaneous or induced	43	122	273,676	293,663	0.77 (0.57 to 1.04)	0.79 (0.59 to 1.07)
Spontaneous	24	122	104,716	293,663	1.00 (0.67 to 1.50)	0.99 (0.66 to 1.48)
Induced	19	122	168,960	293,663	0.59 (0.38 to 0.93)	0.64 (0.41 to 1.00)

CI confidence interval
^aBased on 861 gestations exposed to oseltamivir
^bAdjusted for age at conception, parity, smoking, marital status, obesity, prior delivery of a child with a malformation, respiratory diseases, any other chronic illness [cardiovascular disease, haematological disease, diabetes, neurological disease (including use of antidepressants or antiepileptics), liver or kidney disease, rheumatic disease or inflammatory bowel disease] during 12 months before conception
^cExposure to oseltamivir is analysed as time-varying variable

ISSN: 1471-2334