TY - JOUR AU - Zhang, Wen-Wei AU - Ghosh, Ayan Kumar AU - Mohamath, Raodoh AU - Whittle, Jacqueline AU - Picone, Alessandro AU - Lypaczewski, Patrick AU - Ndao, Momar AU - Howard, Randall F. AU - Das, Pradeep AU - Reed, Steven G. AU - Matlashewski, Greg PY - 2018 DA - 2018/10/03 TI - Development of a sandwich ELISA to detect Leishmania 40S ribosomal protein S12 antigen from blood samples of visceral leishmaniasis patients JO - BMC Infectious Diseases SP - 500 VL - 18 IS - 1 AB - Visceral leishmaniasis (VL), caused by Leishmania donovani complex parasites, is a neglected parasitic disease that is generally fatal if untreated. Despite decades of research to develop a sensitive VL diagnostic test, definitive diagnosis of VL still mainly relies on the visualization of the parasite in aspirates from the spleen, liver or bone marrow, an invasive and dangerous process with variable sensitivity. A sensitive assay that can detect Leishmania antigen from blood samples will help confirm cause, cure or recurrence of VL. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-018-3420-2 DO - 10.1186/s12879-018-3420-2 ID - Zhang2018 ER -