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Table 3 Meta-analysis of each secondary outcome

From: Efficacy and safety of cefazolin versus antistaphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: a systematic review and meta-analysis

Outcome

No. of studies

No. of patients

OR (95% CI)

P Value

I2%

Effects model

Clinical failure

5

778

0.56 (0.37–0.85)

0.12

44.9

Fixed

Recurrence of bacteremia

8

4017

1.12 (0.94–1.34)

0.80

0

Fixed

AEs

5

672

0.37 (0.10–1.41)

0

83.1

Random

Hepatotoxicity

4

645

0.12 (0.04–0.41)

0.51

0

Fixed

Nephrotoxicity

3

484

0.36 (0.16–0.81)

0.88

0

Fixed

Anaphylaxis

5

672

0.91 (0.36–2.99)

0.53

0

Fixed

Hematotoxicity

4

511

0.56 (0.17–1.88)

0.42

0

Fixed

Discontinuation due to AEs

3

468

0.24 (0.12–0.48)

0.30

18

Fixed

  1. AEs adverse effects, CI confidence interval, OR odds ratio