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Fig. 7 | BMC Infectious Diseases

Fig. 7

From: Identity and validity of conserved B cell epitopes of filovirus glycoprotein: towards rapid diagnostic testing for Ebola and possibly Marburg virus disease

Fig. 7

Host specific IgG levels among the negative controls and survivor serum samples. This figure depicts host specific IgG levels among the negative controls and survivor serum samples. Plate A shows IgG levels among 27 runs of the 9 negative controls. The two outliers hits for IgM within negative controls picked by UG-peptide 3 (Fig. 7a) are more likely to be due to either cross reactivity with another pathogen (see Fig. 2, plate B), or higher affinity, rather than the possibility that these were infected samples since they were drawn from a non-VHF endemic setting. Plate B shows 276 runs of 92 survivor serum samples. Note that IgG levels were elevated among survivor serum samples relative to negative controls. Plate C shows results of the differential ability of the 3 epitopes to capture host specific IgG among 282 runs of 94 survivor serum samples. Note the lower IgG titres detected by peptide 1 or 2 relative to peptide 3. These variations might be due to differences in peptide affinity to- and thereby sensitivity for- detecting host specific IgG

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