TY - JOUR AU - Mieras, Liesbeth F. AU - Taal, Anna T. AU - van Brakel, Wim H. AU - Cambau, Emmanuelle AU - Saunderson, Paul R. AU - Smith, W. Cairns S. AU - Prakoeswa, Cita Rosita S. AU - Astari, Linda AU - Scollard, David M. AU - do Nascimento, Dejair Caitano AU - Grosset, Jacques AU - Kar, Hemanta K. AU - Izumi, Shinzo AU - Gillini, Laura AU - Virmond, Marcos C. L. AU - Sturkenboom, Marieke G. G. PY - 2018 DA - 2018/10/05 TI - An enhanced regimen as post-exposure chemoprophylaxis for leprosy: PEP++ JO - BMC Infectious Diseases SP - 506 VL - 18 IS - 1 AB - The ongoing transmission of Mycobacterium (M.) leprae reflected in a very slow decline in leprosy incidence, forces us to be innovative and conduct cutting-edge research. Single dose rifampicin (SDR) as post-exposure prophylaxis (PEP) for contacts of leprosy patients, reduces their risk to develop leprosy by 60%. This is a promising new preventive measure that can be integrated into routine leprosy control programmes, as is being demonstrated in the Leprosy Post-Exposure Programme that is currently ongoing in eight countries. SN - 1471-2334 UR - https://doi.org/10.1186/s12879-018-3402-4 DO - 10.1186/s12879-018-3402-4 ID - Mieras2018 ER -