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Table 4 Characteristics related to the irrigation regimen, ART time and virological failure time associated with virological suppression after 48 weeks from the start of the rescue scheme

From: Virologic suppression in response to antiretroviral therapy despite extensive resistance within HIV-1 reverse transcriptase after the first virologic failure

Viral load (VL)
Characteristics Detectable
n (%)
Undetectable
n (%)
PR PR 95% IC P-value
Time to virologic failure (months)      0, 029a
  < 12 22 (42, 3) 25 (23, 4) 1, 00  
 12–24 13 (25, 0) 45 (42, 0) 0, 48 0, 27 – 0, 84  
  > 24 17 (32, 7) 37 (34, 6) 0, 67 0, 41 – 1, 11  
∆t on ART (months)      0, 022a
  ≤ 36 23 (44, 2) 28 (26, 2) 1, 00  
  > 36 29 (55, 8) 79 (73, 8) 0, 60 0, 39 – 0, 92  
ART rescue NRTI      0, 711b
 TDF/3TC 36 (69, 2) 62 (57, 9) 1, 00  
 AZT/3TC 7 (13, 5) 18 (16, 8) 0, 76 0, 39 – 1, 50  
 TDF/AZT/3TC 7 (13, 5) 19 (17, 8) 0, 73 0, 37 – 1, 45  
 DDI/3TC 0 (0, 0) 1 (0, 9)  
 ABC/3TC 1 (1, 9) 1 (0, 9) 1, 36 0, 33 – 5, 58  
 NNRTI 1 (1, 9) 6 (5, 6) 0, 39 0, 00 – 2, 43  
ART rescue PI      0, 013b
 LPV/r 24 (46, 1) 55 (51, 5) 2, 13 0, 71 – 6, 39  
 ATV/r 20 (38, 5) 33 (30, 8) 2, 64 0, 88–7, 96  
 DRV/r 3 (5, 8) 18 (16, 8) 1, 00  
 FPV/r 5 (9, 6) 1, (0, 9) 5, 83 1, 93 – 17, 65  
ART rescue with RAL      0, 050a
 YES 5 (9, 6) 24 (22, 4) 1, 00  
 NO 47 (90, 4) 83 (77, 6) 2, 10 0, 91 – 4, 81  
GSS      0, 947a
  < 2 8 (15, 4) 15 (14, 0) 1, 11 0, 57 – 2, 14  
 2 22 (42, 3) 44 (41, 1) 1, 06 0, 65 – 1, 72  
  > 2 22 (42, 3) 48 (44, 9) 1, 00  
  1. aChi-square test bFisher’s exact test; PR prevalence ratio, CI Confidence interval, NNRTI nonnucleoside reverse transcriptase inhibitors, NRTI nucleoside/nucleotide reverse transcriptase inhibitors, AZT zidovudine, TAM analogous thymidine mutation, 3TC lamivudine, TDF tenofovir, PI protease inhibitor, LPV/r lopinavir/ritonavir, ATV/r- atazanavir/ritonavir, DRv/r Darunavir/ritonavir, FPV/r fosamprenavir/ritonavir, GSS genotypic sensitivity score