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Table 2 Plasma cytokine and chemokine concentrations in baseline, 6-month follow-up and repeat episodes of syphilis (pg/ml)

From: Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study

  Baseline infection 6 month Repeat infection P-Valuea
IFNα 12.1 (1.6–24.2) 0.8 (0.8–2.6) 0.8 (0.8–0.8) 0.004
IFNγ 1.5 (1.5–8.9) 1.7 (1.5–10.3) 1.54 (1.5–10.6) 0.714
IL1β 1.5 (1.5–1.5) 1.57 (1.5–1.5) 1.57 (1.5–1.5) .
IL12p40 1.0 (1.0–1.0) 1.0 (1.0–1.0) 1.0 (1.0–1.0) .
IL12p70 1.6 (1.6–1.6) 1.6 (1.6–1.6) 1.6 (1.6–1.6) .
IP-10 855.4 (372.7–1143.6) 672.9 (602.6–941.6) 626.3 (462.0–740.4) 0.424
MCP-1 242.1 (212.8–303.1) 278.37(259.2–312.2) 260.7 (225.8–294.0) 0.533
CCL3 1.6 (1.6–4.9) 1.6 (1.6–1.6) 1.6 (1.6–1.6) 0.127
CCL4 17.5 (4.9–32.8) 12.4 (3.5–16.6) 0.9 (0.9–12.1) 0.022
IL-4 1.6 (1.6–1.6) 1.6 (1.6–1.6) 1.6 (1.6–1.6) .
IL-5 1.6 (1.6–1.6) 1.6 (1.6–1.6) 1.6 (1.6–1.6) .
IL-6 1.3 (1.3–1.3) 1.3 (1.3–1.3) 1.3 (1.3–1.3) .
IL-7 1.1 (1.1–1.6) 1.1 (1.1–1.1) 1.1 (1.1–1.1) .
IL-8 2.5 (1.6–5.6) 1.6 (1.6–4.1) 2.1 (1.6–2.4) 0.265
IL-10 1.5 (1.5–31.5) 3.3 (1.9–8.4) 1.8 (1.8–1.9) 0.787
IL-17A 1.5 (1.5–1.5) 1.5 (1.5–1.5) 1.5 (1.5–1.5) 0.489
RPR titre 128 (64–128) 8 (2–16) 32 (16–128) 0.07
  1. All values are median and interquartile range
  2. a P-value is for paired comparison of reinfections with baseline infections (Wilcoxon’s signed rank test)
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