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Table 2 Plasma cytokine and chemokine concentrations in baseline, 6-month follow-up and repeat episodes of syphilis (pg/ml)

From: Syphilis reinfection is associated with an attenuated immune profile in the same individual: a prospective observational cohort study

 

Baseline infection

6 month

Repeat infection

P-Valuea

IFNα

12.1 (1.6–24.2)

0.8 (0.8–2.6)

0.8 (0.8–0.8)

0.004

IFNγ

1.5 (1.5–8.9)

1.7 (1.5–10.3)

1.54 (1.5–10.6)

0.714

IL1β

1.5 (1.5–1.5)

1.57 (1.5–1.5)

1.57 (1.5–1.5)

.

IL12p40

1.0 (1.0–1.0)

1.0 (1.0–1.0)

1.0 (1.0–1.0)

.

IL12p70

1.6 (1.6–1.6)

1.6 (1.6–1.6)

1.6 (1.6–1.6)

.

IP-10

855.4 (372.7–1143.6)

672.9 (602.6–941.6)

626.3 (462.0–740.4)

0.424

MCP-1

242.1 (212.8–303.1)

278.37(259.2–312.2)

260.7 (225.8–294.0)

0.533

CCL3

1.6 (1.6–4.9)

1.6 (1.6–1.6)

1.6 (1.6–1.6)

0.127

CCL4

17.5 (4.9–32.8)

12.4 (3.5–16.6)

0.9 (0.9–12.1)

0.022

IL-4

1.6 (1.6–1.6)

1.6 (1.6–1.6)

1.6 (1.6–1.6)

.

IL-5

1.6 (1.6–1.6)

1.6 (1.6–1.6)

1.6 (1.6–1.6)

.

IL-6

1.3 (1.3–1.3)

1.3 (1.3–1.3)

1.3 (1.3–1.3)

.

IL-7

1.1 (1.1–1.6)

1.1 (1.1–1.1)

1.1 (1.1–1.1)

.

IL-8

2.5 (1.6–5.6)

1.6 (1.6–4.1)

2.1 (1.6–2.4)

0.265

IL-10

1.5 (1.5–31.5)

3.3 (1.9–8.4)

1.8 (1.8–1.9)

0.787

IL-17A

1.5 (1.5–1.5)

1.5 (1.5–1.5)

1.5 (1.5–1.5)

0.489

RPR titre

128 (64–128)

8 (2–16)

32 (16–128)

0.07

  1. All values are median and interquartile range
  2. a P-value is for paired comparison of reinfections with baseline infections (Wilcoxon’s signed rank test)