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Table 4 Phenotypic and genotypic characteristics of 25 pneumococcal strains isolated from children with AOM

From: Resistant Streptococcus pneumoniae strains in children with acute otitis media– high risk of persistent colonization after treatment

No of strain

Serotype

Antibiotic resistance pattern

Site of isolation

Sequence type

Predicted founder ST/CCa

Related PMEN clone

AOM

PT visit

MEF R/L

NP/OP

NP/OP

1

14

PECcSxt

+/+

+/−

+/−

143

156/CC1

Spain 9 V-3 DLV

2

19F

PTeCSxt

−/+

+/−

−/−

423

15/CC3

England 14–9 SLV

3

14

PECcTeSxt

+/−

+/−

NA

156

156/CC1

Spain 9 V-3

5

14

PECcTeSxt

+/−

+/−

+/+

156

156/CC1

Spain 9 V-3

10

19F

PECcTeCSxt

−/+

+/+

−/−

87

88/CC50

 

11

23F

PECcTeCSxt

+/+

+/−

+/+

2033

81/CC13

Spain 23F-1 SLV

14

19F

PECcTeCSxt

+/−

−/−

−/−

87

88/CC50

 

22

22F

S

−/−

−/+

−/−

433

433/CC23

 

27

18C

S

−/+

−/−

−/−

496

496/CC192

 

28

23F

PECcTeSxt

+/+

+/+

+/−

81

81/CC13

Spain 23F-1

30

6B

PECcCSxt

+/+

−/−

−/−

135

473/CC8

 

31

14

PECcSxt

+/+

−/−

−/−

143

156/CC1

 

33

19A

PECcTeSxt

−/−

+/−

−/+

320

320CC2

 

35A

19F

PECcSxt

−/+

−/−

+/−

320

320/CC2

 

35B

19F

PECcSxt

−/−

+/−

−/−

9062

320/CC2

 

41

14

E

+/−

+/−

−/−

9

15/CC3

England 14–9

42

15A

PECcTe

−/−

−/+

+/−

374

63/CC10

Sweden 15A-25 SLV

44

14

PECcTe

−/+

+/−

+/−

10,340

156/CC1

 

48A

14

PECcSxt

−/−

−/−

+/−

10,342

88/CC50

 

48B

14

PECcTeCSxt

−/−

−/−

+/−

15

15/CC3

England 14–9 SLV

49

14

PECcTeSxt

−/−

+/−

+/−

156

156/CC1

Spain 9 V-3

55

14

PECcSxt

−/+

+/−

+/−

15

15/CC3

England 14–9 SLV

56

6B

PECcTeCSxt

−/−

+/−

−/−

135

473/CC8

 

60

3

S

+/+

+/−

−/−

505

180/CC16

 

62

19F

TeCSxt

+/+

−/−

−/−

423

15/CC3

England 14–9 SLV

  1. MEF middle ear fluid, right (R)/left (L) ear, nasopharyngeal(NP)/oropharyngeal(OP) samples, PT post-treatment, P penicillin; E erythromycin, Cc clindamycin, Te tetracycline, C chloramphenicol, Sxt co-trimoxazol, S sensitive to all tested antibiotics, PMEN Pneumococcal Molecular Epidemiology Network, aPredicted founders were assigned by comparing tested strain collection MLST data with whole MLST database