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Table 3 Maternal ART-related adverse effects categorized using the DAIDS Toxicity Grading Scale according to periods of delivery

From: Adverse effects of antiretroviral therapy in pregnant women infected with HIV in Brazil from 2000 to 2015: a cohort study

  2000–2009 (n = 452) 2010–2015 (n = 347) p*
% %
Hemoglobin First Trimester
 Grade 1 92.5 94.6 0.516
 Grade 2 6.4 4.8
 Grade 3 1.1 0.6
Hemoglobin Third Trimester
 Grade 1 83.6 84.9 0.916
 Grade 2 15.5 14.6
 Grade 3 0.9 0.5
AST First Trimester
 Grade 1 98.4 98.9  
 Grade 2 0.7 0.7 1.000
 Grade 3 0.7 0.4  
 Grade 4 0.3 0.0  
AST Third Trimester
 Grade 1 99.4 100.0  
 Grade 2 0.6 0.0 1.000
 Grade 3 0.0 0.0  
 Grade 4 0.0 0.0  
ALT First Trimester
 Grade 1 98.7 98.9  
 Grade 2 0.7 0.7 1.000
 Grade 3 0.3 0.4  
 Grade 4 0.3 0.0  
ALT Third Trimester
 Grade 1 99.4 99.4  
 Grade 2 0.6 0.6 1.000
 Grade 3 0.0 0.0  
 Grade 4 0.0 0.0  
Cholesterol First Trimester
 Grade 1 91.1 90.6 0.631
 Grade 2 6.9 8.4
 Grade 3 2.0 1.0
Cholesterol Third Trimester
 Grade 1 69.7 64.9 0.792
 Grade 2 21.2 24.7
 Grade 3 9.1 10.3
Triglyceride First Trimester
 Grade 1 95.5 94.2 0.820
 Grade 2 4.5 5.3
 Grade 3 0.0 0.5
 Grade 4 0.0 0.0
Triglyceride Third Trimester
 Grade 1 83.3 77.1 0.514
 Grade 2 15.6 20.8
 Grade 3 1.0 2.1
 Grade 4 0.0 0.0
Platelets First Trimester
 Grade 1 98.4 97.2 0.496
 Grade 2 1.1 2.2
 Grade 3 0.0 0.3
 Grade 4 0.5 0.3
Platelets Third Trimester
 Grade 1 99.5 98.8 0.480
 Grade 2 0.5 0.5
 Grade 3 0.0 1.0
 Grade 4 0.0 0.0
Bilirrubin First Trimester
 Grade 1 98.6 95.2 0.264
 Grade 2 1.4 3.0
 Grade 3 0.0 1.8
 Grade 4 0.0 0.0
Bilirrubin Third Trimester
 Grade 1 97.6 93.0 0.200
 Grade 2 1.2 6.1
 Grade 3 1.2 0.9
 Grade 4 0.0 0.0
Total 100 100  
  1. ALT alanine aminotransferase, AST aspartate aminotransferase
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