|  | STUDY PERIOD | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Enrolment | Allocation | During Treatment Months | Post Treatment Months | |||||||||
TIMEPOINT | − 1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | 3 | 6 | 9 | 12 |
ENROLMENT: | ||||||||||||
 Eligibility screen | X |  |  |  |  |  |  |  |  |  |  |  |
 Informed consent | X |  |  |  |  |  |  |  |  |  |  |  |
 Chest X-Ray |  | X |  |  |  |  |  |  |  |  |  |  |
 HIV Testing | X |  |  |  |  |  |  |  |  |  |  |  |
 Urine pregnancy test | X |  |  |  |  |  |  |  |  |  |  |  |
 Allocation |  | X |  |  |  |  |  |  |  |  |  |  |
INTERVENTIONS: | ||||||||||||
 Weekday DOT & weekend self-report |  | X | X | X | X | X | X | X |  |  |  |  |
 PK/PD evaluationa |  |  |  | X |  |  |  |  |  |  |  |  |
 Sputum specimensb |  | X | X | X | X |  | X |  |  |  |  |  |
 Blood specimensc |  | X |  |  |  |  |  |  |  |  |  |  |
ASSESSMENTS: | ||||||||||||
 Side effects screen |  |  | X | X | X | X | X | X |  |  |  |  |
 TLFB |  | X | X | X | X | X | X | X | X | X | X | X |
 Behavioral Assessmentd |  | X |  |  |  |  |  | X |  | X |  | X |
 TB Symptom Screen |  |  |  |  |  |  |  |  | X | X | X | X |