Table 1 TRUST Participant Inclusion and Exclusion Criteria

 ● At least 15 years old

 ● Treated for TB in the last 2 years (defined as at least 1 month of TB treatment)

 ● Initiating TB treatment

 ● Have RIF-resistant TB (RIF resistance will be known at screening from Xpert MTB/RIF)

 ● Expect to remain in the local area for the next 2 years

 ● Extrapulmonary TB

 ● Agree to comply with all study requirements, including provision of contact information and attendance at all study appointments

 ● Contraindication to start on standard 4-drug therapy

 ● Provide written, informed consent to participate in the study if ≥18 years of age or written individual consent and separate parental consent if < 18 years

 ● No documented HIV status from the previous 6 months and refuse HIV testing

 ● Pregnant at study enrollment

 ● History of epilepsy

 ● Do not speak English or Afrikaans

 ● HIV seropositive (for Aim 2 only)