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Fig. 4 | BMC Infectious Diseases

Fig. 4

From: Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort

Fig. 4

Relationship between HCV Antigen test and quantitative PCR for HCV RNA viral load. a Range of HCV RNA viral loads for samples testing HCV-Ag positive (n = 121) and HCV-Ag negative (n = 74). Median and interquartile range shown. P-values by Mann-Whitney U test; ***p < 0.0001. b Relationship between between HCV-Ag and HCV RNA viral load for all samples testing HCV-Ag positive (n = 121). Dashed lines represent threshold for detection for HCV RNA (12 IU/ml) and HCV-Ag (3 fmol/L). Solid line represents linear regression analysis; R2 = 0.3, p < 0.0001. c Percentage of samples testing false-negative for HCV-Ag according to HCV RNA viral load. P-value by Fisher’s Exact test ***p < 0.0001. Data are shown for 128 samples for which both HCV RNA and HCV-Ag testing was undertaken. HCV-Ag was falsely negative (< 3 fmol/L) in 5/13 cases with HCV RNA < 104 IU/ml, and in 2/115 cases with HCV RNA > 104 IU/ml

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