|
Non-acute (n = 312)
|
Acute (n = 145)
|
p-valuea
|
---|
R0 (n = 210)
|
RF (n = 102)
|
---|
% (n)
|
Median Ct
|
IQR
|
% (n)
|
Median Ct
|
IQR
|
% (n)
|
Median Ct
|
IQR
|
---|
Bacteria
|
H. influenzae B
|
83.8 (176)
|
28.3
|
26.5–29.6
|
65.7 (67)
|
29.7
|
28.6–31.4
|
64.8 (94)
|
29.4
|
28.0–31.3
|
0.297
|
H. influenzae non-B
|
31.9 (67)
|
30.2
|
28.4–31.1
|
73.5 (75)
|
24.9
|
22.1–27.1
|
56.6 (82)
|
26.7
|
22.0–29.0
|
< 0.001
|
S. pneumoniae
|
8.1 (17)
|
29.6
|
27.7–30.7
|
34.3 (35)
|
28.0
|
26.1–31.0
|
15.2 (22)
|
27.1
|
26.5–29.2
|
0.706
|
K. pneumoniae
|
14.3 (30)
|
31.2
|
28.3–32.7
|
9.8 (10)
|
29.0
|
26.8–32.0
|
15.9 (23)
|
31.4
|
29.7–32.3
|
0.706
|
S. aureus
|
10.5 (22)
|
31.3
|
30.4–32.5
|
9.8 (10)
|
31.4
|
31.1–32.2
|
6.2 (9)
|
31.1
|
30.6–31.6
|
0.739
|
M. catarrhalis
|
2.4 (5)
|
30.6
|
27.7–31.5
|
3.9 (4)
|
32.6
|
32.2–32.8
|
6.2 (9)
|
29.7
|
29.5–31.5
|
0.564
|
L. pneumophila
|
2.4 (5)
|
32.1
|
31.4–32.4
|
2.0 (2)
|
31.3
|
30.3–32.4
|
2.8 (4)
|
32.5
|
31.2–32.8
|
0.317
|
Viruses
|
Rhinovirus
|
1.9 (4)
|
30.6
|
28.6–31.8
|
15.7 (16)
|
30.2
|
27.2–31.7
|
26.9 (39)
|
28.9
|
26.9–31.4
|
< 0.001
|
Adenovirus
|
0.5 (1)
|
27.2
|
27.2–27.2
|
9.8 (10)
|
30.5
|
29.6–31.4
|
2.8 (4)
|
29.3
|
27.0–31.0
|
0.083
|
Influenza B
|
0 (0)
|
–
|
–
|
0 (0)
|
–
|
–
|
9.7 (14)
|
25.4
|
23.6–31.2
|
–
|
Coronavirus 229
|
1 (2)
|
23.1
|
18.2–28.0
|
2.0 (2)
|
29.3
|
27.2–31.5
|
4.8 (7)
|
26.9
|
25.2–31.3
|
0.034
|
Enterovirus
|
0.5 (1)
|
30.7
|
30.7–30.7
|
4.9 (5)
|
30.2
|
30.1–30.3
|
0 (0)
|
–
|
–
|
–
|
Coronavirus 63
|
1 (2)
|
28.5
|
24.5–32.4
|
1.0 (1)
|
30.0
|
30.0–30.0
|
1.4 (2)
|
22.6
|
21.9–23.3
|
0.157
|
Coronavirus HKU
|
0.5 (1)
|
30.0
|
30.0–30.0
|
0 (0)
|
–
|
–
|
2.1 (3)
|
32.2
|
31.6–32.9
|
–
|
Parainfluenza 2
|
0.5 (1)
|
17.4
|
17.4–17.4
|
1.0 (1)
|
25.3
|
25.3–25.3
|
1.4 (2)
|
23.3
|
20.1–26.5
|
0.564
|
Parainfluenza 4
|
0.5 (1)
|
32.0
|
32.0–32.0
|
0 (0)
|
–
|
–
|
1.4 (2)
|
30.3
|
30.0–30.6
|
0.317
|
Coronavirus 43
|
0.5 (1)
|
28.1
|
28.1–28.1
|
0 (0)
|
–
|
–
|
0.7 (1)
|
32.6
|
32.6–32.6
|
–
|
Bocavirus
|
0.5 (1)
|
17.4
|
17.4–17.4
|
0 (0)
|
–
|
–
|
0 (0)
|
–
|
–
|
–
|
Influenza A
|
0 (0)
|
–
|
–
|
0 (0)
|
–
|
–
|
0.7 (1)
|
29.9
|
29.9–29.9
|
–
|
- ap-value for difference in proportion of positive samples in non-acute samples collected at the start (R0) of the training period or acute samples from individuals who developed URI during follow-up, as computed by McNemar test