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Table 2 Normalized gene expression values of whole blood leukocytes samples of leprosy patients with reactions (n = 94) and leprosy patients without reactions (n = 57)

From: Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes

Reaction vs No Reaction

Gene

Description

log fold change

p.value*

CCL2

C-C Motif Chemokine Ligand 2

4.04

0.0016

PARK

parkinson protein 2, E3 ubiquitin protein ligase

3.27

0.0036

ALOX5

Arachidonate 5-Lipoxygenase

2.99

0.0108

TLR7

Toll Like Receptor 7

2.98

0.011

LRRK2

Leucine Rich Repeat Kinase 2

3.09

0.0161

IFNB

interferon beta 1

2.36

0.0228

TLR10

Toll Like Receptor 10

3.07

0.0236

IL18

Interleukin 18

2.34

0.0326

TLR3

Toll Like Receptor 3

2.74

0.0338

CLEC5A

C-Type Lectin Domain Containing 5A

2.81

0.0446

RR vs No Reaction

 CCL2

C-C Motif Chemokine Ligand 2

4.31

0.0002

 TLR7

Toll Like Receptor 7

3.81

0.0012

 PARK

parkinson protein 2, E3 ubiquitin protein ligase

3.16

0.002

 ALOX5

Arachidonate 5-Lipoxygenase

3.32

0.0044

 LRRK2

Leucine Rich Repeat Kinase 2

3.28

0.0056

 IFNB

interferon beta 1

2.64

0.0104

 TLR10

Toll Like Receptor 10

3.08

0.0122

 TLR3

Toll Like Receptor 3

3.04

0.0122

 IL18

Interleukin 18

2.65

0.014

 OAS1

2′-5′-oligoadenylate synthetase 1

2.51

0.0376

 IL15

Interleukin 15

2.42

0.0446

ENL vs No Reaction

 PARK

parkinson protein 2, E3 ubiquitin protein ligase

2.13

0.0436

ENL vs RR

 TLR7

Toll Like Receptor 7

−2.72

0.0214

  1. *The genes were defined as differentially expressed by the criterion of p-value adjusted for multiple comparisons. Bayesian statistical analysis used a log fold change cutoff of > 1 and adjusted p value of < 0.05. - Abbreviations: RR reversal reaction, ENL erythema nodosum leprosum