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Table 1 Clinical characteristics of 111 patients identified as BALF CMV positive or negative, Soochow, 2014–2017

From: Associations between patient clinical characteristics and the presence of cytomegalovirus DNA in the bronchoalveolar lavage fluid of children with recurrent wheezing

Variable BALF CMV positive (n = 57) BALF CMV negative (n = 54) P-value
Age, median (IQR), months 11.0 (6.0–21.5) 14.5 (9.7–23.0) 0.133
Male, n (%) 42 (73.7) 43 (79.6) 0.460
Breastfeeding, n (%) 35 (61.4) 30 (55.6) 0.532
≥ 2 children in household, n (%) 34 (59.6) 37 (68.5) 0.331
Length of hospitalization, median (IQR), days 11.0 (9.0–13.2) 11.0 (8.0–13.0) 0.001
Peripheral blood eosinophils, median (IQR), % 0.7 (0.3–1.3) 0.9 (0.2–2.3) 0.385
IgE, median (IQR), IU/mL 77.1 (11.1–132.2) 46.4 (9.2–160.6) 0.833
Subpopulation of lymphocytes, median (IQR), %
 CD19+CD23+ 13.6 (10.5–19.4) 13.3 (9.9–18.1) 0.383
 CD3+ 61.3 (52.4–70.9) 65.1 (52.6–70.3) 0.626
 CD3+ CD4+ 35.0 (26.9–39.7) 35.3 (31.4–45.1) 0.063
 CD3+CD8+ 24.3 (17.6–28.6) 18.5 (15.6–26.2) 0.023
 CD3CD16+CD56+ 9.6 (6.3–13.1) 8.9 (5.4–11.7) 0.647
 CD3CD19+ 24.6 (18.2–31.1) 21.9 (17.6–30.6) 0.482
Humoral immunity, median (IQR), g/L
 Total IgA 0.43 (0.16–0.66) 0.32 (0.16–0.59) 0.273
 Total IgM 0.89 (0.68–1.46) 0.9 (0.63–1.36) 0.700
 Total IgG 6.09 (4.91–7.93) 5.73 (4.25–7.92) 0.254
Cytology of BALF, median (IQR), %
 Macrophages 50.0 (13.5–87.0) 54.0 (24.5–82.5) 0.554
 Neutrophils 38.0 (10.0–77.5) 36.5 (12.0–62.0) 0.437
 Lymphocytes 4.0 (2.0–9.5) 5.0 (2.0–6.7) 0.954
 Eosinophils 0.0 (0.0–2.0) 0.5 (0.0–6.0) 0.027
  1. BALF bronchoalveolar lavage fluid, CMV cytomegalovirus
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