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Table 3 Association of initial levels of oxidative stress markers with endpoints

From: Association of the Tyrosine/Nitrotyrosine pathway with death or ICU admission within 30 days for patients with community acquired pneumonia

Entire Cohort (n = 278) Adverse outcome at 30d 6 year Mortality
OR (95% CI); p-value HR (95% CI); p-value
Tyrosinea
 Univariate 3.30 (0.63 to 17.36), p = 0.159 1.88 (0.90 to 3.91), p = 0.093
 Multivariateb 0.84 (0.15 to 4.65), p = 0.841 1.58 (0.72 to 3.47), p = 0.256
 AUROC 0.55 (0.44 to 0.66) 0.60 (0.54 to 0.67)
Tyr-NO2a
 Univariate 0.65 (0.35 to 1.20), p = 0.167 0.96 (0.73 to 1.27), p = 0.778
 Multivariateb 0.44 (0.20 to 0.96), p = 0.039 0.81 (0.6 to 1.1), p = 0.181
 AUROC 0.43 (0.31 to 0.56) 0.50 (0.42 to 0.58)
Ratio Tyr-NO2/Tyrosine
 Univariate 0.91 (0.81 to 1.02), p = 0.098 0.99 (0.95 to 1.02), p = 0.457
 Multivariateb 0.98 (0.97 to 0.99), p = 0.043 1.00 (0.99 to 1.00), p = 0.216
 AUROC 0.42 (0.30 to 0.53) 0.48 (0.40 to 0.56)
  1. aValues were log-transformed; b Multivariate analysis adjusted for PSI-Class (≤3 vs ≥4) BMI and comorbidities