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Table 4 Incidence rates and adjusted incidence rate ratios of severe hepatotoxicity: main analysis and sensitivity analysis

From: Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

  Total person-days Number of outcome events (incidence rate per 30 person-days) Adjusted IRR (95% CI)P-values
Anidulafungin Caspofungin Micafungin Anidulafungin Caspofungin Micafungin Anidulafungin versus caspofungin Anidulafungin versus micafungin
Main analysis
Sample: all patients
Outcome: severe hepatotoxicity
26449 85020 102267 633 (0.72) 993 (0.35) 1522 (0.45) 1.43 (1.14, 1.79)*
0.002*
1.19 (0.92, 1.54)
0.183
Sensitivity analyses
Subgroup: patients with normal LFT at baseline (Grade 0)
Outcome: severe hepatotoxicity
6538 23703 33926 26 (0.12) 67 (0.08) 131 (0.12) 0.88 (0.36, 2.14)
0.773
0.97 (0.46, 2.08)
0.945
Subgroup: patients with normal to moderately elevated LFT at baseline (Grades 0–2)
Outcome: severe hepatotoxicity
20102 69188 84415 154 (0.23) 343 (0.15) 513 (0.18) 1.46 (0.91, 2.37)
0.119
1.62 (0.95, 2.77)
0.078
Sample: all patients
Outcome: all-cause in-hospital death
38246 104801 126348 581 (0.46) 1188 (0.34) 1544 (0.37) 1.26 (1.07, 1.48)*
0.007*
0.93 (0.77, 1.12)
0.444
  1. *P-value < 0.05
  2. Abbreviations: CI confidence interval, IRR incidence rate ratio, LFT liver function test