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Table 1 Hepatotoxicity grade by liver function test

From: Retrospective cohort study comparing the risk of severe hepatotoxicity in hospitalized patients treated with echinocandins for invasive candidiasis in the presence of confounding by indication

Liver function test Hepatotoxicity gradea
Grade 0 Grade 1 Grade 2 Grade 3 Grade 4
Aspartate transaminase AST ≤ ULN AST > ULN and AST ≤ 2.5 x ULN AST > 2.5 x ULN and AST ≤ 5 x ULN AST > 5 x ULN and AST < 20 x ULN AST ≥ 20 x ULN
Alanine aminotransferase ALT ≤ ULN ALT > ULN and ALT ≤2.5 x ULN ALT > 2.5 x ULN and ALT ≤5 x ULN ALT > 5 x ULN and ALT < 20 x ULN ALT ≥20 x ULN
Total bilirubin Bilirubin ≤ ULN Bilirubin > ULN and bilirubin ≤1.5 x ULN Bilirubin > 1.5 x ULN and bilirubin ≤3 x ULN Bilirubin > 3 x ULN and bilirubin ≤10 x ULN Bilirubin > 10 x ULN
  1. Abbreviations: ALT alanine aminotransferase, AST aspartate transaminase, ULN upper limit of the normal
  2. aHepatotoxicity cut-offs were adapted from the Clinical Islet Transplantation study–Terminology Criteria for Adverse Events in trials of adult pancreatic islet transplantation (CIT-TCAE) Version 5.0 [13], which are modified standards of those set forth in the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) [14]